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Table 1 Mechanisms of resistance to sunitinib and everolimus

From: Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

Potential mechanisms of sunitinib resistance

   Hypoxia resistance of RCC cells

   Vascular resistance to VEGFR and PDGFR inhibition by sunitinib

Potential mechanisms of everolimus resistance

   Resistance of RCC cells to direct anti-proliferative everolimus effects

   Resistance of HIF1α target gene expression to repression by everolimus

   Hypoxia resistance of RCC cells

   Vascular resistance to VEGF pathway inhibition

  1. PDGFR, platelet derived growth factor receptor; RCC, renal cell carcinoma; VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor.
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Genome Medicine

ISSN: 1756-994X

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