Figure 2

Screenshots representing the basic information provided by the wKinMut system for analyzing a set of point mutations in protein kinases [147, 148]. The panels present: (a) general information about the protein kinase imported from various databases; (b) information about the possible consequences of the mutations extracted from annotated databases, each linked to the original source; (c) predictions of the consequences of the mutations in terms of the principal features of the corresponding protein kinase, including the results of the kinase-specific system KinMut [110] (Table 2); (d) an alignment of related sequences, including information about conserved and variable positions; (e) the position of the mutations in the corresponding protein structure (when available); (f) sentences related to the specific mutations from [77]; (g) information about the function and interactions of the protein kinase extracted from PubMed with the iHOP system [149, 150]. A detailed description of the wKinMut system can be found in [147] and in the documentation of the web site [148].