A map of human microRNA variation uncovers unexpectedly high levels of variability

Table 1 Summary of variant positions found

Origin	Population	Subjects	SNVs	SNVs in dbSNP	SVNs in precursor	SVNs in mature	Number of heterozygous	Number of homozygous	miRNA with disease	Diseases
European	IBS	14	78	75	70	15	52	26	21	76
	AND	60	92	77	81	21	55	37	30	82
	CEU	85	132	119	116	29	87	45	42	102
	TSI	98	147	127	120	32	104	43	120	109
	GBR	89	131	114	110	28	80	51	43	107
	FIN	93	118	103	102	25	72	46	36	95
Asian	CHS	100	114	92	93	28	65	49	30	88
	CHB	97	123	99	104	25	77	46	30	91
	JPT	89	120	108	103	32	72	42	38	96
American	MXL	66	132	111	110	34	82	50	38	90
	PUR	55	152	141	117	35	107	45	41	85
	CLM	60	141	124	114	28	90	51	37	88
African	LWK	97	229	187	179	59	158	71	70	104
	ASW	61	206	177	158	54	145	60	60	108
	YRI	88	207	175	169	53	130	77	169	133

Origin, geographical origin of the population; Population, population code according to the 1000 Genomes Project (see Materials and methods); Subjects, number of sequenced subjects per population; SNVs, number of SNVs found in the population; SNVs in dbSNP, how many of these variants are already described in dbSNP; SVNs in precursor, how many of the SNVs map within the miRNA precursor structure (Figure 3, bottom); SVNs in mature, how many of the SNVs map within the miRNA mature structure (Figure 2, bottom); Number of heterozygous, the number of times that the SNV occurred heterozygously; Number of homozygous, the number of times that the alternative allele occurred homozygously; miRNA with disease, the number of miRNAs associated with at least one known disease, with at least one SNV, in the corresponding population; Diseases, the total number of diseases with which the miRNAs are associated.

ISSN: 1756-994X