From: Genome-wide approaches for identifying genetic risk factors for osteoporosis
Subjects and samples | Treatment | Differentially expressed genes | Important regulated genesa | Refs |
---|---|---|---|---|
Human osteoblasts isolated from trabecular bone tissue of femoral neck and proximal femur | Comparing the gene expression profiles of osteoblasts from osteoporotic versus non-osteoporotic bone tissues | 1,606 | Upregulated: IBSP, CXCL2; downregulated: PTN, COL15A1 | [62] |
Human MSCs | Oleanolic acid | 256 | Genes involved in osteoblastic differentiation | [69] |
 | Ex vivo long-term cultivation |  | ID4, CRYAB, SORT1, TGF-β2, and BMPs | [64] |
 | Cell culture |  | NDN, EPHA5, NOV, RUNX2 | [65] |
Human monocytes of low BMD subjects | Isolation from human blood | 13 | STAT1 | [60] |
Differentiation and proliferation of mouse osteoblast cells | High cholesterol | 992 upregulated, 2,290 downregulated | Upregulated: TGF-β, BMP2, CBFA1, and proteins involved in Wnt signaling pathways; downregulated: IL-6 and AGER | [61] |
Bone resorption and formation of male mice in high-fat diet | Antioxidant lipoic acid | 17 upregulated, 19 downregulated | Upregulated: COL1A1, ALP1, IGF-1, and IL12; downregulated: MMP9, CTSK, P53, TGFBR1, and IL17a | [66] |
Both pairs of femora and tibiae of Sprague-Dawley female rats | Three different PTH peptides, PTH(1-34), (1-31), and (3-34) | Â | Slpi, tfpi2, socs3, gro1, RANKL, phex, Gprc5c, and CXCR4 | [70] |