From: Genome-wide approaches for identifying genetic risk factors for osteoporosis
Participants or cells/treatment | Identified protein expression | Related functions/pathways | Refs |
---|---|---|---|
Human bone MSCs | 64 secreted proteins upregulated, especially SMOC1 | Osteoblast mineralization | [82] |
Human PBMs | ANXA2 | Osteoclast differentiation | [39] |
Human osteocytes | LRP4 | A sclerostin interaction partner | [87] |
Chinese with low BMD | SOD 2 upregulated | Located in circulating monocytes (potential osteoclast precursors) | [89] |
Osteoblast differentiation in mouse osteoprogenitor MC3T3-E1 cells | Upregulation of IQGAP1, gelsolin, moesin, radixin, and CFL1 | Cytoskeleton regulation | [79] |
 | Upregulation of FLNA, LAMA1, LAMA5, COL1A1, COL3A1, COL4A6, COL5A2; downregulation of COL4A1, COL4A2, and COL4A4 | Focal adhesion signaling | [79] |
Osteoblast differentiation in MC3T3-E1 preosteoblast cells/ leukocyte common antigen-related tyrosine phosphatase | ALP, BSP, DLX5, OCN, and RUNX2 | Erk activation | [80] |
Osteoblasts and osteoclasts induced from RAW 264.7 macrophage cell line (from murine blood)/Er-Xian Decoction treatment | In osteoblasts: 8 proteins upregulated | Hmgb1, acidic ribosomal phosphoprotein P0, histone H2, carbonyl reductase 1, ATP synthase, aldolase A, and GDIα | [78] |
 | In osteoblasts: 3 proteins downregulated | Carbonic anhydrase 3, prohibitin, hemiferrin, far upstream element-binding protein | [78] |
 | In osteoclasts: 3 proteins upregulated | Vimentin, protein disulfide isomerase associated 3 and α-fetoprotein | [78] |
 | In osteoclasts: 1 protein downregulated | Calnexin | [78] |
Rat primary calvarial osteoblast/Kaempferol | 9 proteins upregulated, 9 downregulated | Including cytoskeletal proteins, intracellular signaling protein, chaperone, extracellular matrix protein, and proteins involved in glycolysis and cell-matrix interactions | [77] |
Ovariectomized rats | SOD1, ATP synthase, and COMT | Protection against bone loss | [90] |