From: Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics
sCNA | Frequency in CLL (%) | Likely target | Frequency in MBL (%) | More common IGHV status | Prognostic significance |
---|---|---|---|---|---|
del(13q14) | miR-15a/16, encoded in an intron of DLEU2 [8]. Its deletion leads to the release of BCL2 from microRNA-mediated down-regulation [28] | 48 [112] | None | Good [9] | |
del(11q22.3) | ATM, BIRC3 | Rare | Unmutated | Poor [9] | |
Trisomy 12 | Unknown [7] | 20 [112] | None | None [9] | |
del(17p) | TP53 | Rare | Unmutated | Poor [9] | |
amp(2p) | 7 [27] | XPO1, BCL11A | Unknown | Unmutated | None [27] |
amp(8q24.21) | MYC | Unknown | Unmutated | ||
del(15q15.1) | 4 [27] | MGA | Unknown | Unknown | None [27] |
del(10)(q24) | 2 [27] | NFKB2 | Unknown | Unknown | Unknown |
del(18p) | 3 [27] | Unknown | Unknown | Unmutated [27] | Unknown |
del(6q) | 7 [27] | Unknown | Unknown | Unknown | Unknown |
amp(3q26.32) | 6 [26] | PIK3CA | Unknown | Unknown | Poor [26] |
del(8p) | Unknown | Unknown | Unknown | Poor [26] |