Figure 1

Genome-wide view of human s-DMRs. Pooled DNA from uncultured whole blood cell samples including both sexes (all 60% male) were analyzed for each species. Methylated fragments via MeDIP-seq were aligned to the appropriate species’ genome; then peaks were called within these, using two peak-calling algorithms (MACS v1.4.1 [47] and BayesPeak v1.8 [48]). Triangulation reciprocal LiftOver [49] comparison then identified human s-DMRs. Outer ring, human chromosomes; blue ring, hypermethylated human s-DMRs (15,858); yellow ring, hypomethylated human s-DMRs (22,758); green ring, CNV density; inner ring, gene density.