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Table 2 Genetic and functional effect of mutations in oncogenes and tumor suppressors

From: DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes

  

Functional effect

  

Gain

Loss

Genetic effect

Dominant

Typical OG

Dominant negative TSG

Recessive

None

Typical TSG

  1. A driver cancer gene is defined by a genetic effect (dominant, recessive) and a functional effect (gain or loss). These two components ultimately define the tumor suppressor and oncogene characteristics that we try to infer from the mutational landscape (structural effect).
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Genome Medicine

ISSN: 1756-994X

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