Race and ancestry in biomedical research: exploring the challenges
- Timothy Caulfield1Email author,
- Stephanie M Fullerton2,
- Sarah E Ali-Khan3,
- Laura Arbour4,
- Esteban G Burchard5,
- Richard S Cooper6,
- Billie-Jo Hardy3,
- Simrat Harry1,
- Robyn Hyde-Lay7,
- Jonathan Kahn8,
- Rick Kittles9,
- Barbara A Koenig10,
- Sandra SJ Lee11,
- Michael Malinowski12,
- Vardit Ravitsky13,
- Pamela Sankar13,
- Stephen W Scherer14,
- Béatrice Séguin3, 15,
- Darren Shickle16,
- Guilherme Suarez-Kurtz17 and
- Abdallah S Daar3, 18, 19, 20
© BioMed Central Ltd 2009
Published: 21 January 2009
The use of race in biomedical research has, for decades, been a source of social controversy. However, recent events, such as the adoption of racially targeted pharmaceuticals, have raised the profile of the race issue. In addition, we are entering an era in which genomic research is increasingly focused on the nature and extent of human genetic variation, often examined by population, which leads to heightened potential for misunderstandings or misuse of terms concerning genetic variation and race. Here, we draw together the perspectives of participants in a recent interdisciplinary workshop on ancestry and health in medicine in order to explore the use of race in research issue from the vantage point of a variety of disciplines. We review the nature of the race controversy in the context of biomedical research and highlight several challenges to policy action, including restrictions resulting from commercial or regulatory considerations, the difficulty in presenting precise terminology in the media, and drifting or ambiguous definitions of key terms.
Recent advances in biomedical research promise increasing insights into complex contributions to traits and diseases, and there is hope that these will lead to global health benefits [1, 2]. Analytical and social-justice considerations both recommend thoughtful assessment of the role of social identity, particularly racial or ethnic identity, in the design, conduct and dissemination of clinical and basic science research. Controversies ranging from James Watson's comments on racial differences in intelligence  to the adoption of racially targeted pharmaceuticals, such as the African-American heart-failure drug BiDil [4–7], remind us that use of the concept of race in biomedical research can have far-reaching, often unanticipated social consequences.
The problem of race in scientific research is not a new one, and the issue seems to perpetually reappear and remain fundamentally unresolved . We are, however, entering a new era in which the fruits of initiatives, such as the Human Genome Project [9, 10], the International Haplotype Map Project , and the recently proposed 1000 Genomes Project , promise to elaborate more fully than ever before the nature and extent of human genetic variation and its relation to social identity. A recent interdisciplinary workshop, 'Ancestry in health and medicine; expanding the debate', hosted by the Alberta Health Law Institute and the McLaughlin-Rotman Centre for Global Health, in Toronto, Canada, sought to debate the current status and concerns surrounding these new scientific data, how we relate genetic variation to individual and population-level differences in observable traits, and what this might mean for the effective addressing of significant disparities in health status and disease. A central motivating consideration was how best to secure the anticipated benefits of genetic and related forms of biomedical research in the face of inevitable misunderstandings or misuse concerning genetic variation and race.
Here, we draw together the perspectives of the scholars who participated in the workshop, who have considered the race issue from the vantage point of a variety of disciplines: anthropology, bioethics, clinical medicine, ethical, social, cultural studies, genetic epidemiology, genome sciences, global heath research, law and the social sciences. We review the nature of the race controversy in the context of biomedical research and highlight several challenges to policy action.
The race dilemma in research
Persistent disagreements about how best to understand race as an object of scientific inquiry complicate matters further. Racial definitions can fluctuate according to social context, geographic location, historical period and personal experience. Indeed, it is not uncommon for the same individual to report their racial identity differently in different contexts and at different points in their lives [15–17]. For these and related reasons many scholars view racial identity as primarily a social construct [18–22], and one that can misdirect the categorization of participants in biomedical research. Others see racial identity as correlated with a mix of social and biological risk factors that should be recognized and disentangled, even used to advantage, in an effort to explain and address health disparities [23–26].
Despite research correlating population genetic identity with geographic proximity [27–30], many researchers hold that self-identified racial or ethnic identity is a poor proxy for underlying genetic relatedness [31–34]. As a consequence, scientists with an interest in identifying genetic-association studies with disease are turning to DNA-based estimates of 'ancestry' as a basis for stratifying study samples and controlling for background genetic differences unrelated to disease risk [35–37]. Geneticists have also begun to use ancestry informative markers (AIMs) to identify groups and individuals subject to recent genetic admixture and use this information in methods such as admixture mapping [38–40]. In both gene-association and admixture studies, assessing ancestry is seen as preferable because it circumvents the problems of self-reporting, although major axes of differentiation continue to be drawn along continental lines, recapitulating previously used racial distinctions: African, European, Native American, and so on.
Although ancestry estimation has the potential to control biases due to genetic confounding, in isolation its use defers, rather than addresses, the important problem of how social and biological risk factors interact in the context of health - including the production of racial health disparities. Research that simultaneously assesses both genetic and environmental contributions to disease risk, drug response and other health-related variation, and that deliberately puts such findings in the context of self-identified race, is urgently needed [13, 41–43]. In the absence of such additional evidence, and despite its amorphous nature, the multi-dimensional and contested concept of race will probably continue to have an important place in biomedical research for many years to come.
Challenges to change
How can we move forward? Many journals, research entities and academic commentators have provided relevant recommendations (Box 2). Yet concerns persist, and race and related concepts continue to be used in an inconsistent and potentially misleading manner within biomedical research [44, 48–50].
The concept of race has a long and complex social history , and the research community operates within the constraints imposed by this history and its associated social structures. This overriding reality is one of the primary reasons why the use of race remains a controversial and uneasy concept in research. However, there are other challenges that make progress difficult, despite the numerous policy recommendations. Understanding these tendencies, trends and social forces may help us to more effectively use existing recommendations and address social concerns. What follows, although not comprehensive, is a list of some of the most salient challenges that emerged from the workshop.
Commercial and regulatory imperatives
Decisions on whether or how to use race in biomedical research and clinical practice do not take place in isolation. Often they are shaped by commercial and regulatory imperatives that reward or require the use of racial categories in particular ways that may not serve constructive purposes. Much biomedical data, for example, is produced as a result of regulatory mandates that direct the collection of data using social categories of race derived from such sources as national census tables [13, 46, 52, 53]. Such 'racialized' data necessarily raise questions of how best to manage the relationship between social census categories of race and the biomedical data being produced by researchers and clinicians. Moreover, once introduced into the biomedical arena, race can take on a life of its own, leading to the retrospective framing of data and/or the prospective design of product development in 'racialized' terms that were not originally contemplated by the researchers [54–56]. It also seems likely that market forces will push toward terminology that captures a larger population and has more immediate public recognition . Narrowly defined terms, such as ancestry, are likely to have less public recognition than race.
The popular press is an important source of health information, particularly for the general public . Although the relationship between media representations and public perceptions of biomedical research is complex , there is some evidence that the media can influence social perceptions and attitudes, even about race . There are certainly examples of news reports that include a thorough examination of the challenges associated with using race in biomedical research , but media representations often simplify the science and use concepts such as race without explaining how the social category relates to the research outcome . Given the limited space and time available to write most science stories, this is hardly surprising. The research community, in an effort to translate the research results to the lay public, can also use terminology that does not accurately reflect or represent the research conducted (Box 2). For example, a study might have used ancestry as a variable but, in its media report, racial descriptors are used to describe the significance of the findings in the popular press .
Definition drift and slippage
In response to the social concerns associated with the notion of race, new terminology has been suggested - the hope being that this new terminology will be both more scientifically precise and have less historical and social baggage. For example, the term ethnicity emerged as an alternative to race . However, there is often a migration back to the origin term or the new term simply comes to be understood to mean the same thing as the old one . Given that the social category of race has the most cultural resonance, this slippage is likely to be from the more specific terminology toward the broader, and perhaps more inaccurate, notion of race [26, 62].
The final challenge is the need to strategically tolerate the ambiguity of racial identity. Because, as described above, the relevance of race and of race categories far exceeds the arena of scientific discourse and becomes the concern of government regulation, media accounts and language debate, science cannot independently dictate its meaning or invent new terms to replace it. Moreover, the features that make race socially useful - its fluidity, ambiguity and contingency - and that feed its social ubiquity and thus contribute to its scientific utility also work against tidy definitions. These features of race cannot be reasoned away. Nor, however, can they be used as an excuse to ignore standard scientific requirements for explaining research terms and justifying design choices. Instead, they need to be recognized and self-consciously engaged, as part of an iterative process directed at clarifying the import of human genetic variation in the long term and of using genetic insights to help eliminate, rather than reinforce, disparities in health status.
Race is best understood as the result of a process informed by social values and institutional practices that imbue superficial differences between groups, such as skin color, eye shape or language, with unwarranted significance. Historically, this has been informed by hierarchical thinking, in which group differences and social inequalities are naturalized and rearticulated as biological realities . Genomic research that uses racial categories in the investigation of genetic contributions to disease can also inadvertently support such 'racialization' and influence how findings of group differences are interpreted and, in turn, translated into clinical care and health policy.
Clearly, although the recognition that certain susceptibility variants are more prevalent in certain groups can have health benefits, such observations should not validate the politically and historically charged concept of race or support assumptions that the entire range of attributes ascribed to race have a biological basis. There is a need to develop strategies to mitigate the inappropriate and potentially inaccurate use of categorizing terminology. The available recommendations, outlined in Box 2, have merit. But there are numerous social forces and tendencies, such as those outlined above, that challenge progress towards constructive change.
Future policy and social-science work should focus on exploring the influence of these social forces. For example, although some research in this area has already been done [62, 67], a more nuanced understanding of how data on human genomic variation are interpreted by media, and in turn assimilated by the public, is needed. Recommendations for communication strategy could be used to raise the awareness of researchers as to how their work is apprehended by lay audiences (Box 2), especially journalists. Engagement and education of both scientists and media on their social and ethical responsibilities would be a related actionable strategy (Box 2). In the arena of clinical trials and genetic epidemiological research, the social impact and scientific utility of alternative methods of subject identification and reporting of findings could be explored. Most importantly, consideration should be given not only to ensuring that relevant policy recommendations are effectively implemented, but that they are being followed.
Finally, it must be recognized that the discussion and analysis surrounding the use of race, ethnicity or ancestry in medicine is, for the most part, flowing from scholars in North America and Europe. However, a number of countries, including Mexico, India [68, 69], Thailand and South Africa, are already doing, or planning to undertake, projects studying human genetic diversity within their own populations; and in many others, such as Brazil, extensive admixture has created a continuum of ancestral proportions among individuals that challenge racial classification. It will therefore be important that experts from communities in both the emerging economies and developing countries also contribute to this very important debate.
Additional data files
The following file is available: Additional data file 1 , consisting of an extended version of Box 1 that includes supporting quotations from the cited references for each example concern.
The Toronto workshop was co-hosted by McLaughlin-Rotman Centre for Global Health, University Health Network, University of Toronto (ASD) and the Health Law Institute, University of Alberta (TC). We thank Genome Alberta and the Advanced Food and Material Network for funding support. The McLaughlin-Rotman Centre for Global Health Program on Life Sciences Ethics and Policy is primarily supported by Genome Canada through the Ontario Genomics Institute and the Bill and Melinda Gates Foundation. Other matching partners are listed at .
- Collins FS, Green ED, Guttmacher AE, Guyer MS, : A vision for the future of genomics research. Nature. 2003, 422: 835-847.PubMedView ArticleGoogle Scholar
- Daar AS, Singer PA: Pharmacogenetics and geographical ancestry: implications for drug development and global health. Nat Rev Genet. 2005, 6: 241-246.PubMedView ArticleGoogle Scholar
- Black people 'less intelligent' scientist claims. http://www.timesonline.co.uk/tol/news/uk/article2677098.ece
- Taylor AL, Ziesche S, Yancy C, Carson P, D'Agostino R, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN, : Combination of isosor-bide dinitrate and hydralazine in blacks with heart failure. New Engl J Med. 2004, 351: 2049-2057.PubMedView ArticleGoogle Scholar
- Sankar P, Kahn J: BilDil: race medicine or race marketing. Health Affairs. 2005, Suppl Web Exclusives: W5-455-63.Google Scholar
- Temple R, Stockbridge NL: BiDil for heart failure in black patients: The U.S. Food and Drug Administration perspective. Ann Intern Med. 2007, 146: 57-62.PubMedView ArticleGoogle Scholar
- Seguin B, Hardy B, Singer PA, Daar AS: Bidil: recontextualizing the race debate. Pharmacogenomics J. 2008, 8: 169-173.PubMedView ArticleGoogle Scholar
- Weiss KM, Fullerton SM: Racing around getting nowhere. Evol Anthropol. 2005, 14: 165-169. 10.1002/evan.20079.View ArticleGoogle Scholar
- Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Bladwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stang-Thomann N, : Initial sequencing and analysis of the human genome. Nature. 2001, 409: 860-921.PubMedView ArticleGoogle Scholar
- Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Brider S, Clark AG, Nadeau J, McKusick VA, Zinder N: The sequence of the human genome. Science. 2001, 291: 1304-1351.PubMedView ArticleGoogle Scholar
- International HapMap Consortium: A haplotype map of the human genome. Nature. 2005, 437: 1229-1320.View ArticleGoogle Scholar
- 1000 Genomes. http://www.1000genomes.org
- Braun L, Fausto-Sterling A, Fullwiley D, Hammonds EM, Nelcon A, Quivers W, Reverby SM, Shields AE: Racial categories in medical practice: how useful are they?. PLoS Med. 2007, 9: e271-10.1371/journal.pmed.0040271.View ArticleGoogle Scholar
- Montoya MJ: Bioethnic conscription: Genes, race, and mexicana/o ethnicity in diabetes research. Cult Anthropol. 2007, 22: 94-128. 10.1525/can.2007.22.1.94.View ArticleGoogle Scholar
- Surratt HL, Inciardi JA: Unraveling the concept of race in Brazil: issues for the Rio de Janeiro Cooperative Agreement site. J Psychoactive Drugs. 1998, 30: 255-260.PubMedView ArticleGoogle Scholar
- Eschbach K, Supple K, Snipp CM: Changes in racial identification and the educational attainment of American Indians. Demography. 1998, 35: 35-43.PubMedView ArticleGoogle Scholar
- Hitlin S, Scott JB, Elder GHJ: Racial self-categorization in adolescence: multiracial development and social pathways. Child Dev. 2006, 77: 1298-1308.PubMedView ArticleGoogle Scholar
- Anonymous: AAA statement on race. Am Anthropol. 1998, 100: 712-713. 10.1525/aa.19220.127.116.112.View ArticleGoogle Scholar
- Anonymous: Genes, drugs and race. Nat Genet. 2001, 29: 239-240.View ArticleGoogle Scholar
- Collins FS, Mansoura MK: The Human Genome Project. Revealing the shared inheritance of all humankind. Cancer. 2001, 91: 221-225.PubMedView ArticleGoogle Scholar
- Schwartz RS: Racial profiling in medical research. New Engl J Med. 2001, 344: 1392-1393.PubMedView ArticleGoogle Scholar
- Cooper RS: Race, genes, and health - new wine in old bottles?. Int J Epidemiol. 2003, 32: 23-25.PubMedView ArticleGoogle Scholar
- Risch N, Burchard E, Ziv E, Tang H: Categorization of humans in biomedical research: genes, race and disease. Genome Biol. 2002, 3: comment2007Google Scholar
- Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Perez-Stable EJ, Sheppard D, Risch N: The importance of race and ethnic background in biomedical research and clinical practice. New Engl J Med. 2003, 348: 1170-1175.PubMedView ArticleGoogle Scholar
- Choudhry S, Seibold MA, Borrell LN, Tang H, Serebrisky D, Chapela R, Rodriguez-Santana JR, Avila PC, Ziv E, Rodriguez-Cintron W, Risch NJ, Burchard EG: Dissecting complex diseases in complex populations: asthma in latino americans. Proc Am Thorac Soc. 2007, 4: 226-233.PubMedPubMed CentralView ArticleGoogle Scholar
- Koenig B, Lee SSJ, Richardson S: Revisiting Race in a Genomic Age. 2008, New Brunswick: Rutgers University PressGoogle Scholar
- Bowcock AM, Ruiz-Linares A, Tomfohrde J, Minch E, Kidd JR, Cavailli-Sforza LL: High resolution of human evolutionary trees with polymorphic satellites. Nature. 1994, 368: 455-457.PubMedView ArticleGoogle Scholar
- Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA, Feldman MW: Genetic structure of human populations. Science. 2002, 298: 2381-2385.PubMedView ArticleGoogle Scholar
- Jakobsson M, Scholz SW, Scheet P, Gibbs JR, VanLiere JM, Fung HC, Szpiech ZA, Degnan JH, Wang K, Guerreiro R, Bras JM, Schymick JC, Hernandez DG, Traynor BJ, Simon-Sanchez J, Matarin M, Britton A, Leemput van de J, Rafferty I, Bucan M, Cann HM, Hardy JA, Rosenberg NA, Singleton AB: Genotype, haplotype and copy-number variation in worldwide human populations. Nature. 2008, 451: 998-1003.PubMedView ArticleGoogle Scholar
- Li JZ, Absher DM, Tang H, Southwick AM, Casto AM, Ramchandran S, Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM: Worldwide human relationships inferred from genome-wide patterns of variation. Science. 2008, 319: 1100-1104.PubMedView ArticleGoogle Scholar
- Wilson JF, Weale ME, Smith AC, Gatrix F, Fletcher B, Thomas MG, Bradman N, Goldstein DB: Population genetic structure of variable drug response. Nat Genet. 2001, 29: 265-269.PubMedView ArticleGoogle Scholar
- Serre D, Paabo S: Evidence for gradients of human genetic diversity within and among continents. Genome Res. 2004, 14: 1679-1685.PubMedPubMed CentralView ArticleGoogle Scholar
- Barnholtz-Sloan JS, Chakraborty R, Sellers TA, Scwartz AG: Examining population stratification via individual ancestry estimates versus self-reported race. Cancer Epidemiol Biomarkers Prev. 2005, 14: 1545-1551.PubMedView ArticleGoogle Scholar
- Suarez-Kurtz G, Vargens DD, Struchiner CJ, Bastos-Rodrigues L, Pena SD: Self-reported skin color, genomic ancestry and the distribution of GST polymorphisms. Pharmacogenet Genomics. 2007, 17: 765-771.PubMedView ArticleGoogle Scholar
- Hoggart CJ, Parra EJ, Shriver MD, Bonilla C, Kittles RA, Clayton DG, McKeigue PM: Control of confounding of genetic associations in stratified populations. Am J Hum Genet. 2003, 72: 1492-1504.PubMedPubMed CentralView ArticleGoogle Scholar
- Reiner AP, Ziv E, Lind DL, Nievergelt CM, Schork NJ, Cummings SR, Phong A, Burchard EG, Harris TB, Psaty BM, Kwok PY: Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. Am J Hum Genet. 2005, 76: 463-477.PubMedPubMed CentralView ArticleGoogle Scholar
- Choudhry S, Coyle NE, Tang H, Salari K, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard D, Shriver MD, Rodriguez-Clinton W, Risch N, Ziv E, Burchard EG, : Population stratification confounds genetic association studies among Latinos. Hum Genet. 2006, 118: 652-664.PubMedView ArticleGoogle Scholar
- Shriver MD, Parra EJ, Dios S, Bonilla C, Norton H, Jovel C, Pfaff C, Jones C, Massac A, Cameron N, Baron A, Jackson T, Argyropoulos G, Jin L, Hoggart CJ, McKeigue PM, Kittles RA: Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet. 2003, 112: 387-399.PubMedGoogle Scholar
- Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA: A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet. 2005, 37: 1113-1118.PubMedView ArticleGoogle Scholar
- Zhu X, Luke A, Cooper RS, Quertermous T, Hanis C, Mosely T, Gu CC, Tang H, Rao DC, Risch N, Weder A: Admixture mapping for hypertension loci with genome-scan markers. Nat Genet. 2005, 37: 177-181.PubMedView ArticleGoogle Scholar
- Krieger N: Stormy weather: race, gene expression, and the science of health disparities. Am J Public Health. 2005, 95: 2155-2160.PubMedPubMed CentralView ArticleGoogle Scholar
- Krieger N: Defining and investigating social disparities in cancer: critical issues. Cancer Causes Control. 2005, 16: 5-14.PubMedView ArticleGoogle Scholar
- Masi CM, Olopade OI: Racial and ethnic disparities in breast cancer: a multilevel perspective. Med Clin North Am. 2005, 89: 753-770.PubMedView ArticleGoogle Scholar
- Shanawani H, Dame L, Scwartz S, Cook-Deegan R: Non-reporting and inconsistent reporting of race and ethnicity in articles that claim association among genotype, outcome and race or ethnicity. J Med Ethics. 2006, 32: 724-728.PubMedPubMed CentralView ArticleGoogle Scholar
- L'Observatoire de la genetique: ’Race’ is Not a Scientific Concept: Alternative Directions. http://www.ircm.qc.ca/bioethique/obsgenetique/cadrages/cadr2005/c_no24_05/ca_no24_05_01.html
- Fullwiley D: The molecularization of race: institutionalizing human difference in pharmacogenetics practice. Sci Cult. 2007, 16: 1-30. 10.1080/09505430601180847.View ArticleGoogle Scholar
- Sankar P, Cho MK, Mountain J: Race and ethnicity in genetic research. Am J Med Genet A. 2007, 143A: 961-970.PubMedView ArticleGoogle Scholar
- Ma IW, Khan NA, Kang A, Zalunardo N, Palepu A: Systematic review identified suboptimal reporting and use of race/ethnicity in general medical journals. J Clin Epidemiol. 2007, 60: 572-578.PubMedView ArticleGoogle Scholar
- Hunt LM, Megyesi MS: The ambiguous meanings of the racial/ethnic categories routinely used in human genetics research. Soc Sci Med. 2008, 66: 349-361.PubMedPubMed CentralView ArticleGoogle Scholar
- Hunt LM, Megyesi MS: Genes, race and research ethics: who's minding the store?. J Med Ethics. 2008, 34: 495-500.PubMedPubMed CentralView ArticleGoogle Scholar
- Frederickson GM: Racism: A Short History. 2002, Princeton, New Jersey: Princeton University PressGoogle Scholar
- United States Code 1993: National Institutes of Health Revitalization Act of. 1993, . Public Law 103-143, 131-151. Codified as amended at 42 USC 283-290: Statute 122, 133-140Google Scholar
- NIH Policy and Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research. http://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm
- Lee SS: Racializing drug design: implications of pharmacogenomics for health disparities. Am J Public Health. 2005, 95: 2133-2138.PubMedPubMed CentralView ArticleGoogle Scholar
- Kahn J: How a drug becomes 'ethnic': law, commerce, and the production of racial categories in medicine. Yale J Health Policy Law Ethics. 2004, 4: 1-46.PubMedGoogle Scholar
- Kahn J: Genes, race and population: avoiding a collision of categories. Am J Public Health. 2006, 96: 1965-1970.PubMedPubMed CentralView ArticleGoogle Scholar
- Caulfield T: Nutrigenomics, popular representations and the reification of 'race'. Health Law Rev. 2008, 16: 50-57.Google Scholar
- Geller G, Tambor ES, Bernhardt BA, Rodgers J, Holtzman NA: Houseofficers' reactions to media coverage about the sequencing of the human genome. Soc Sci Med. 2003, 56: 2211-2220.PubMedView ArticleGoogle Scholar
- Bates B: Public culture and public understanding of genetics: a focus study. Public Underst Sci. 2004, 13: 1-19.Google Scholar
- Condit CM, Parrott RL, Bevan J, Bates BR, Achter PJ: Exploration of the impact of messages about genes and race on lay attitudes. Clin Genet. 2004, 66: 402-408.PubMedView ArticleGoogle Scholar
- Caulfield T, Harry S: Popular representations of race: the news coverage of BiDil. J Law Med Ethics.Google Scholar
- Condit CM: How geneticists can help reporters to get their story right. Nat Rev Genet. 2007, 8: 815-820.PubMedView ArticleGoogle Scholar
- Sankar P: Hasty generalizations and exaggerated certainties: Reporting genetic findings in health disparities research. New Genet Soc. 2006, 25: 249-254. 10.1080/14636770601032759.View ArticleGoogle Scholar
- Smart A, Tutton R, Ashcroft R, Martin PA, Ellison GTH: Can science alone improve the measurement and communication of race and ethnicity in genetic research? Exploring the strategies proposed by Nature Genetics. Biosocieties. 2006, 1: 313-324. 10.1017/S1745855206003036.View ArticleGoogle Scholar
- Sankar P, Cho MK: Genetics. Toward a new vocabulary of human genetic variation. Science. 2002, 298: 1337-1338.PubMedPubMed CentralView ArticleGoogle Scholar
- Omi M, Winant H: Racial Formation in the United States: from the 1960's to the 1990's. 1986, New York: RoutledgeGoogle Scholar
- Bubela TM, Caulfield TA: Do the print media "hype" genetic research? A comparison of newspaper stories and peer-reviewed research papers. CMAJ. 2004, 170: 1399-1407.PubMedPubMed CentralView ArticleGoogle Scholar
- Indian Genome Variation Consortium: The Indian Genome Variation database (IGVdb): a project overview. Hum Genet. 2005, 118: 1-11.View ArticleGoogle Scholar
- Indian Genome Variation Consortium: Genetic landscape of the people of India: a canvas for disease gene exploration. J Genet. 2008, 87: 3-20.View ArticleGoogle Scholar
- Templeton A: Human races: A genetic and evolutionary perspective. Am Anthropol. 1998, 100: 632-650. 10.1525/aa.1918.104.22.1682.View ArticleGoogle Scholar
- Long JC, Kittles RA: Human genetic diversity and the nonexistence of biological races. Hum Biol. 2003, 75: 449-471.PubMedView ArticleGoogle Scholar
- Keita SO, Boyce AJ: "Race": confusion about zoological and social taxonomies, and their places in science. Am J Hum Biol. 2001, 13: 569-575.PubMedView ArticleGoogle Scholar
- Oppenheimer GM: Paradigm lost: race, ethnicity, and the search for a new population taxonomy. Am J Public Health. 2001, 91: 1049-1055.PubMedPubMed CentralView ArticleGoogle Scholar
- Cooper RS, Kaufman JS, Ward R: Race and genomics. New Engl J Med. 2003, 348: 1166-1170.PubMedView ArticleGoogle Scholar
- Collins FS: What we do and don't know about 'race', 'ethnicity', genetics and health at the dawn of the genome era. Nat Genet. 2004, 36 (11 Suppl): S13-S15.PubMedView ArticleGoogle Scholar
- Sankar P, Cho MK, Mountain J: Race and ethnicity in genetic research. Am J Med Genet A. 2007, 143A: 961-970.PubMedView ArticleGoogle Scholar
- Lee SS, Mountain J, Koenig BA: The meanings of "race" in the new genomics: implications for health disparities research. Yale J Health Policy Law Ethics. 2001, 1: 33-75.PubMedGoogle Scholar
- Braun L: Race, ethnicity, and health: can genetics explain disparities?. Perspect Biol Med. 2002, 45: 159-174.PubMedView ArticleGoogle Scholar
- Sankar P, Cho MK, Condit CM, Hunt LM, Koenig B, Marshall P, Lee SS, Spicer P: Genetic research and health disparities. JAMA. 2004, 291: 2985-2989.PubMedPubMed CentralView ArticleGoogle Scholar
- Center for American Progress. http://www.americanprogress.org
- Rotimi CN: Are medical and nonmedical uses of large-scale genomic markers conflating genetics and 'race'?. Nat Genet. 2004, 36 (11 Suppl): S43-S47.PubMedView ArticleGoogle Scholar
- Duster T: Medicine. Race and reification in science. Science. 2005, 307: 1050-1051.PubMedView ArticleGoogle Scholar
- Brewer RM: Thinking critically about race and genetics. J Law Med Ethics. 2006, 34: 513-519. 480.PubMedView ArticleGoogle Scholar
- Clayton EW: The complex relationship of genetics, groups, and health: what it means for public health. J Law Med Ethics. 2002, 30: 290-297.PubMedView ArticleGoogle Scholar
- Brandt-Rauf SI, Raveis VH, Drummond NF, Cont JA, Rothman SM: Ashkenazi Jews and breast cancer: the consequences of linking ethnic identity to genetic disease. Am J Public Health. 2006, 96: 1979-1988.PubMedPubMed CentralView ArticleGoogle Scholar
- Outram SM, Ellison GTH: Anthropological insights into the use of race/ethnicity to explore genetic contributions to disparities in health. J Biosoc Sci. 2006, 38: 83-102.PubMedView ArticleGoogle Scholar
- Braun L: Reifying human difference: the debate on genetics, race, and health. Int J Health Serv. 2006, 36: 557-573.PubMedView ArticleGoogle Scholar
- Graves JL, Rose MR: Against racial medicine. Patterns Prejudice. 2006, 40: 481-493. 10.1080/00313220601020189.View ArticleGoogle Scholar
- Suarez-Kurtz G: The implications of population admixture in race-based drug prescription. Clin Pharmacol Ther. 2008, 83: 399-400.PubMedView ArticleGoogle Scholar
- Race, Ethnicity and Genetics Working Group: The use of racial, ethnic, and ancestral categories in human genetics research. Am J Hum Genet. 2005, 77: 519-532.View ArticleGoogle Scholar
- Winker M: Measuring race and ethnicity: why and how?. JAMA. 2004, 292: 1612-1614.PubMedView ArticleGoogle Scholar
- Rivara FP, Finberg L: Use of the terms race and ethnicity. Arch Pediatr Adolesc Med. 2001, 155: 119-PubMedView ArticleGoogle Scholar
- Kaplan JB, Bennett T: Use of race and ethnicity in biomedical publication. JAMA. 2003, 289: 2709-2716.PubMedView ArticleGoogle Scholar
- Anonymous: Ethnicity, race and culture: guidelines for research, audit and publication. BMJ. 1996, 312: 1094-View ArticleGoogle Scholar
- Greely HT: Informed consent and other ethical issues in human population genetics. Annu Rev Genet. 2001, 35: 785-800.PubMedView ArticleGoogle Scholar
- Condit CM, Parrott R, Harris TM: Lay understandings of the relationship between race and genetics: development of a collectivized knowledge through shared discourse. Public Understand Sci. 2002, 11: 373-387. 10.1088/0963-6625/11/4/305.View ArticleGoogle Scholar
- Foster MW, Sharp RR, Freeman WL, Chino M, Berstein D, Carter TH: The role of community review in evaluating the risks of human genetic variation research. Am J Hum Genet. 1999, 64: 1719-1727.PubMedPubMed CentralView ArticleGoogle Scholar
- The International HapMap Consortium, : Integrating ethics and science in the International HapMap Project. Nat Rev Genet. 2004, 5: 467-475.PubMed CentralView ArticleGoogle Scholar
- CMAJ Editorial Policies. http://www.cmaj.ca/authors/policies.shtml
- Iverson C, Flanagin A, Fontanarosa PB, Glass RM, Giltman P, Lantz JC, Meyer HS, Smith JM, Winker MA, Young RK: American Medical Association Manual of Style: a Guide for Authors and Editors. 1998, Baltimore: Williams and Wilkins, 9Google Scholar
- Anonymous: Census, race and science. Nat Genet. 2000, 24: 97-98.View ArticleGoogle Scholar
- CSE's white paper on promoting integrity in scientific journal publications. http://www.councilscienceeditors.org/editorial_policies/whitepaper/2-1_editor.cfm
- Genetics in Medicine. Online Submission and Review System. http://edmgr.ovid.com/gim/accounts/ifauth.htm
- Uniform requirements for manuscripts submitted to biomedical journals: writing and editing for biomedical publication. http://www.icmje.org
- Committee on Pediatric Research: Race/ethnicity, gender, socioeconomic status - research exploring their effects on child health: a subject review. Pediatrics. 2000, 105: 1349-1351.View ArticleGoogle Scholar
- McLaughlin-Rotman Centre for Global Health. http://www.mrcglobal.org