Figure 2From: Mutation signatures implicate aristolochic acid in bladder cancer developmentMutation spectra and strand bias of examples of cancers with and without evidence for AA exposure. (A,B) Bladder cancers (33324197T, B77). (C) Bladder cancer with statistically significant over-representation of A:T > T:A mutations and strand bias but with a pattern of trinucleotide contexts for A:T > T:A mutations notably dissimilar from tumors with known AA exposure (TCGA-K4-A6FZ-01A-11D-A31L-08). (D) HCC (HK41T). (E) For comparison, a bladder cancer (TCGA-FD-A6TE-01A-12D-A339-08) without evidence of AA exposure. Plotting conventions are as for Figure 1. In total, 6 of 349 bladder cancers showed evidence of AA exposure (Figure S1 in Additional file 1).Back to article page