Fig. 3
From: Designing string-of-beads vaccines with optimal spacers
Fold change in cleavage likelihood and differences in neo-immunogenicity compared for 1000 randomly sampled epitope pairs. Spacers of lengths 1–6 were designed with the described model. The cleavage probability (a) and immunogenicity (b) were compared for epitope pairs concatenated without a spacer sequence, epitope pairs combined with a commonly used spacer sequence (AAY), and pairs combined with optimally designed spacers. Black error bars represent the 68 % confidence intervals