Fig. 3

Genera with significant differences between cases and controls, non-responders and responders. a –Log₁₀(p value) from testing difference in abundance of each genus in cases compared to controls and non-responders compared to responders. Blue bars indicate taxa negatively associated with case or non-responder status, and red bars indicate a positive association. The line below 2 represents the threshold for nominal significance; the higher line is the significance level after Bonferroni adjustment for multiple tests. The asterisks denote taxa that also appear in the results of our random forest classifier. b–d Example patterns representative of each of the three categories: b significant in both comparisons, c significant only between cases and controls, and d significant only between non-responders and responders. (See also Additional file 2: Table S6.)