Research area | Key findings | Reference(s) |
---|---|---|
Genome sequencing | WGS and refinement of genome sequences of primate and rodent infectious Plasmodium species | |
 | Genome sequence of cryptic chimpanzee Plasmodium species | [158] |
Gene expression regulation | Discovery of AP2-G as master regulator of gametocytogenesis in Pf and Pb | |
 | AP2-G2 functions as a transcription regulator driving gametocyte development | [51] |
 | Functional analysis of Pf lifecycle dynamics using transcriptional profiling | [180] |
 | Genome-wide TSS mapping in Pf | [42] |
 | Acetylome analysis reveals post-translational PTM of ApiAP2 transcription factors | [55] |
 | Genome-wide analysis of AP2-O target genes | [48] |
Post-transcriptional/translational control | Genome-wide analysis reveals features of the Pf translatome | |
 | Analysis of the Pb maternal repressome | [64] |
Epigenetic control | SETvs functions as a regulator of var gene silencing in Pf | [98] |
 | Involvement of HP1 in clonal variant gene expression and sexual development | [29] |
 | HDA2 mediates var gene silencing and sexual commitment in Pf | [27] |
 | BDP1 regulates expression of invasion-related genes | [31] |
 | Profiling of histone PTMs in Pf | [22] |
Gene silencing/editing | First description of the use of ZFN and CRISPR-Cas9 genome editing in Plasmodium | |
 | Functional adaptation of an AID-based conditional knockdown system in Pb | [159] |
Antibiotic resistance | Analysis of KELCH13-propellermutations in Plasmodium field isolates confirms relation to artemisinin resistance | |
 | Identification of UPR pathway involvement in Plasmodium artemisinin resistance | |
Genome structure | First profiling of genome-wide chromosome interactions | [39] |
 | Strong correlation between spatial genome structure and gene expression | [37] |
ncRNAs | PfRNaseII exonuclease is involved in group A var gene silencing | [84] |
 | Genome-wide search revealed over 1000 novel ncRNAs in Pf | [181] |
 | Strand-specific RNA sequencing reveals widespread transcription of antisense RNAs in Pf | |
 | Antisense lncRNAs regulate expression of cognate var genes in Pf | [87] |
Virulence/transmission | Vector transmission of P. chabaudi chabaudi impacts on parasite virulence | [182] |
 | Transcriptome changes during early phase of mosquito infection | [183] |
Development | Global phosphoproteome analysis identified PKG as major intracellular Ca2+ level regulator | [184] |
 | PKG regulates Plasmodium egress and evasion | [185] |
 | Systematic subtractive bioinformatic analysis identified sex-specific stage V gametocyte protein marker | [186] |
 | Protein phosphatases are key regulators of Plasmodium development | [187] |
Population genomics | Identification of a novel malaria resistance locus through GWAS in African children | [5] |
 | Genomic epidemiology study revels global KELCH13 mutation distribution | [160] |
Metablomics | Lipid metabolism analysis in Pf | [151] |