Fig. 3
From: 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Examples of mutational 3D clusters in tumor suppressor genes. a Residues in 3D clusters in PTEN highlighted in the protein sequence (top) and a protein structure (bottom). The 3D cluster residues surround the catalytic site. b Residues in 3D clusters in CDH1 (E-cadherin) highlighted in the protein sequence (top) and a protein structure (bottom). The 3D cluster mutations are likely to disrupt the critical calcium-binding site (calcium atoms in red). c 3D clusters in KEAP1 in the protein sequence (top) and a protein structure (bottom). Most of the 3D cluster mutations are in the NRF2-binding region (NRF2 peptide in purple)