Fig. 7From: Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypesSummary of the survival and growth phenotypes in breast cancer. The survival phenotype is characterized by high HER2, IGF1R, and AKT pathway activation, high expression of pro-apoptotic BIM, low expression of anti-apoptotic MCL-1, and response to HER2, AKT, PI3K, and mTOR inhibitors. The growth phenotype is characterized by high EGFR, KRAS, and RAF1 activation, high expression of MCL-1, low expression of BIM, and response to EGFR/MEK-targeted therapies and chemotherapiesBack to article page