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Fig. 6 | Genome Medicine

Fig. 6

From: Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Fig. 6

Overexpression and de-methylation of FGFR1 in acquired cetuximab resistance is confirmed in stable SCC25-resistant clones. a Expression of FGFR1 relative to DNA methylation in stable cetuximab-resistant clones. b QRT-PCR of FGFR1 gene expression in CTXR10 relative to the parental cell line (> 30-fold change). c Western blot comparing FGFR1, phospho-FGFR1, EGFR, and phospho-EGFR in CTXR10 relative to the parental SCC25 cell line. In the resistant cell clone, increased levels of FGFR1 were associated with increased levels of phospho-FGFR1 and decrease in EGFR and phospho-EGFR

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Genome Medicine

ISSN: 1756-994X

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