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Fig. 8 | Genome Medicine

Fig. 8

From: Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

Fig. 8

Potential dysregulation of C3AR1 in MAPT pathogenic variant carriers. A C3AR1 expression was enriched in the NC monocyte cluster (11). B C3AR1 expression in NC monocytes was significantly reduced in MAPT variant carriers (*pFDR = 2.2 × 10.−23). C ddPCR analysis of PBMC RNA revealed a trend toward reduced expression of C3AR1 in MAPT variant carriers which did not reach significance (p = 0.12)

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Genome Medicine

ISSN: 1756-994X

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