Fig. 3
From: CCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation
Rag2del mice demonstrate an attenuated CCR2 macrophage and increased monocyte response following cardiomyocyte transplantation. A Flow cytometric analysis of the cardiac immune response at D4 and D7 post MI. Values are represented as mean ± SEM. N = 7 in all groups and time points. Significance was calculated using the Mann–Whitney test. *p ≤ 0.05, **p ≤ 0.01. B Assessment of CD68+ cells in the remote area of the heart 4 weeks after MI. CD68+ cells are stained red and the nuclei are stained blue using DAPI. Scale bar represents 20 μm. ‘MI’ refers to the infarct group, and ‘MI-CM’ refers to the cell transplanted group. Values are represented as mean ± SEM. N = 7,7,7,5. Significance between the respective MI and MI-CM groups were calculated using an unpaired two-tailed t test. **p ≤ 0.01, ***p ≤ 0.001