Fig. 5
From: ClinPrior: an algorithm for diagnosis and novel gene discovery by network-based prioritization
HSP/CA expanded interactome. A The HSP/CA seeds + expanded network was generated by the network prioritization tool, resulting in 2187 proteins. The seed genes known to be mutated in HSP/CA are shown in yellow circles, disease genes not previously associated with HSP/CA are shown in green, and new HSP/CA candidate genes are shown in blue. Comparison of the statistical connectivity strength of the HSP/CA expanded network with 1000 permutations of randomly selected proteins from the global human network. Red dots denote the value of the metric on the HSP/CA expanded network constituted by 2187 proteins. Box and whisker plots denote matched null distributions (i.e. 1000 permutations). (Left) Within-group edge count (i.e. number of edges between members of the query set). (Right) Mean distance is the average path length in the network obtained by calculating the shortest paths between all pairs of proteins. B–F Zoom-in on the network for specific putative candidates as illustrative examples of the potential of the HSP/CA expanded network: B serine hydroxymethyltransferase 2 (SHMT2); C ubiquitin-associated protein 1 (UBAP1); D phosphate cytidylyltransferase 2, ethanolamine (PCYT2); E p2,4-dienoyl-CoA reductase 1 (DECR1); and F eukaryotic translation initiation Factor 2 subunit alpha (EIF2S1). * Indicates recently associated with HSP/CA