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Fig. 3 | Genome Medicine

Fig. 3

From: Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Fig. 3

Intercellular interaction analysis. A HCC-immune interaction analysis identified the activation of the PAX5 network. B, C HCC-CAF interaction analysis pointed to the activation of the FOS and JUN networks. D PAX5 is a transcription factor that regulates B cell activity, and the PAX5 network identified co-localizes with the distribution of B cells as determined by the spatial distribution of B cell markers. E FOS and JUN are transcription factors that can regulate genes involved in extracellular matrix remodeling, and the networks regulated by these genes colocalize with CAF marker genes

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Genome Medicine

ISSN: 1756-994X

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