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Fig. 5 | Genome Medicine

Fig. 5

From: Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Fig. 5

Intercellular interaction analysis in the context of intra-sample heterogeneity. A Intercellular interaction analysis in the immune-rich tumor region (cancer-immune) reveals activation of PAX5. B, C FOS and JUN are the active networks from the interaction analysis at the immune-poor tumor region (HCC-CAF). D PAX5 activation co-localizes with the expression of B cell markers concentrated at the borders of the immune-rich tumor region. E FOS and JUN networks are co-expressed with CAF markers adjacent to the immune-poor tumor region

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Genome Medicine

ISSN: 1756-994X

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