Fig. 6
From: Interplay of Mendelian and polygenic risk factors in Arab breast cancer patients
The interactions between age and polygenic risk score (PRS) conditioned on family breast cancer history (1st-degree relative) and pathogenic variant (PV) carrier status. The overall cohort had no significant correlation between age and PRS (gray line in all panels) but among patients with first-degree relatives diagnosed with breast cancer, age of onset is negatively correlated with PRS in patients with no detected pathogenic variants (top right panel). A similar trend can also be seen among PV carriers with no family history of breast cancer (bottom left panel)