Fig. 7

PRS Performance improves when pathogenic variants are accounted for. a The proportion of patients in different PRS deciles having a family history of breast cancer or other cancers. b The proportion of patients in different PRS deciles having a family history of breast cancer or other cancers after PV carriers are removed. c The performance of the PRS at detecting familial cancer risk before and after removing PV carriers from the cohort, as measured by AUC. P-values are based on the proportion of samples with lower AUC after removing PV carriers from 10,000 bootstrapped samples of the dataset. AUC delta refers to the relative difference in AUC after removing PV carriers in the original cohort