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Fig. 3 | Genome Medicine

Fig. 3

From: Revealing the developmental origin and lineage predilection of neural progenitors within human bone marrow via single-cell analysis: implications for regenerative medicine

Fig. 3

Characterization of subpopulations within BMSC-derived neurospheres. A Dot plot showing the marker expression levels of different clusters within BMSC-neurospheres. NC3 highly expressed CTNNB1, PTN, NRN1, GDF6, IGFBP5, FEZ1, ETV5, CLU and GAS7 which relate to neural development. NC5 highly expressed genes related to osteogenesis (DLX5, RUNX2, SPP1, IBSP) and vasculature formation (VEGFA, ANTXR1). B UMAP visualization of 5 clusters (NC1-NC5) identified within BMSC-neurospheres under unsupervised clustering. C The reconstructed pseudotime trajectory showed NC4 as the developmental starting state and NC3 and NC5 as the end states. D Functional enrichment analysis revealed that both NC3 and NC5 possessed the potential for neural differentiation. E Projections of NC3 and NC5 upon the integrated dataset. F The top 5 regulons in NC3 and NC5 clusters are highlighted in red, and regulon specificity scores (RSS) shown upon the Y-axis as inferred from the SCENIC algorithm

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Genome Medicine

ISSN: 1756-994X

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