Fig. 5
From: Analysis of transcriptomic features reveals molecular endotypes of SLE with clinical implications
SHAP analysis reveals features most distinctive of transcriptional perturbations in the seven abnormal lupus endotypes
SHAP analysis of the seven binary RF classifiers distinguishing the seven out of eight most transcriptionally abnormal lupus endotypes (B–H) from the eighth least abnormal endotype (A) reveals the features most contributory to the ML model’s classification capacity. Mean SHAP values were calculated using only the samples in each more severe endotype (B–H) that were positive. The size of the data points enumerates the positive mean SHAP value of each feature listed on the y-axis. Bubble plot rendered in R using the ggplot2 package