Fig. 8

The relationship between LuCIS value and clinical variables, flares or clinical response

Pearson correlations were computed between LuCIS values and A anti-dsDNA titers, B SLEDAI, C serum C3, and D serum C4 using LuCIS values of all the patients from GSE88884 ILL-1 & ILL-2 (n = 1620). LuCIS values were divided into sextiles for GSE88884 ILL-1 & ILL-2 and E incidence of subsequent flares over 52 weeks in placebo patients receiving SoC medication (n = 550) was examined. LuCIS values were also divided into sextiles for GSE88884 ILL-2, and F SRI-4 response and G SRI-5 response were examined. Significant associations between incidence of flare among the sextiles (denoted with asterisks in the title) were identified using the chi-square test for trend. Differences in incidence of flare between sextiles were determined by chi-square test of independence and denoted below the figure. Similarly, responses among the treatment groups in each LuCIS sextile independently were determined by the chi-square test for trend (all three doses) or chi-square test for independence. Significant results of the chi-square test for trend are denoted in the plot title. All plots were generated, and statistics were computed, in GraphPad Prism v. 9.5.0 (730). *p < 0.05; **p < 0.01; ***p < 0.001