Fig. 2
Forest plots of the associations of pathway PRSs with metabolic measures in individuals with type 2 diabetes from three cohorts. A HbA1C (n = 18,517). B BMI (n = 21,281). C HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) (n = 2241). D HDL cholesterol (n = 19,370). E Triglycerides (n = 20,797). F Alanine transaminase (n = 19,134). G gamma-glutamyl transferase (n = 16,900). H Chronic kidney disease (n = 19,171). I Cardiovascular disease (n = 20,504). Linear regression was conducted for continuous outcomes (A,C,D,E,F,G) and logistic regression for binary (H,I) controlling for age, sex, BMI, and cohort, besides BMI (B) which was controlled for sex and cohort. See Additional file 1: Table S8 for the numbers underlying this figure