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Fig. 3 | Genome Medicine

Fig. 3

From: Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Fig. 3

We assessed the causal association between BMI and T2D by comparing the effect sizes of genetic variants mapping to insulin resistance, beta-cell deficiency, and obesity pathway. Regression lines represent causal estimates from Mendelian randomization (MR) methods inverse variance weighted (IVW) regression and Egger regression. Lines represent one standard error. A The effect of genetic variants within the obesity pathway with BMI as exposure and T2D as outcome. B The effect of variants within the IR (insulin resistance) pathway with T2D as exposure and BMI as outcome. C The effect of variants within the beta-cell deficiency pathway with T2D as exposure and BMI as outcome. D Bar plots depicting r-squared of genetic variants on both BMI and T2D with the resulting Steiger Z-test p-values

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Genome Medicine

ISSN: 1756-994X

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