Fig. 8
From: Using multi-scale genomics to associate poorly annotated genes with rare diseases
EvORanker’s performance in identifying candidate disease genes using mouse knockout genes without corresponding human annotation. A The graph shows the percentage of genes with mouse knockout phenotypes that were tested for significant p-values using EvORanker. Out of 6260 genes, 41% showed significant p-values. B Comparison of EvORanker and Phenolyzer [49] in identifying true disease gene candidates. The graph shows the count of genes with mouse knockout phenotypes and their respective ranking, each in comparison to 100 randomly sampled genes by EvORanker and Phenolyzer. Among the tested genes, 16% were ranked in the top 10 by both tools