Table 1 Summarized overview of the number of 5'UTR variants that remained after functional classification and filtering

uAUG gained

30

5

35

2.41

Change in existing uORF

17

1

18

1.24

Alteration of classical or retinal primary Kozak context

16

7

23

1.59

Splicing

29

10

39

2.69

Change in translational efficiency

1

0

1

0.07

Change in secondary structure minimum free energy

194

43

237

16.34

Overlapping a retinal transcription start site or an IRES

692

69

761

52.48

> 1 category

276

60

336

23.17

Total

1255

195

1450