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Fig. 1 | Genome Medicine

Fig. 1

From: Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Fig. 1

Single-cell transcriptomic landscape of epithelial cells and fibroblasts in pancreatic cancer. A Experimental workflow and data preprocessing steps. B UMAP projection of five major cell populations identified in the CD45-negative cell population of pancreatic cancer. C Predicted copy number alterations across the major cell populations. D UMAP projection of epithelial cell subclusters with their specific markers. E Relative abundance of epithelial subclusters in the proliferating population. Enrichment scores were calculated by dividing each subcluster’s fraction in the proliferating epithelial population (Ep_CDK1) by the fraction in the non-proliferating population. Bar colors indicate the significances tested by proportion z-tests: red (significant enrichment), black (significant depletion). F Fibroblast-stellate cell subclusters with their specific markers. G Relative abundances of fibroblast-stellate subclusters in the proliferating population as in E

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Genome Medicine

ISSN: 1756-994X

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