Fig. 4

Transcription factor network regulating pancreatic cancer cell clusters. A Specific transcription factor activities across cancer cell clusters. The top five transcription factors showing specific activities for each cancer cell cluster are shown. B Transcription factor network in the pancreatic epithelial cell population. Edge widths are proportional to the correlation coefficients between the transcription factor pairs. Node colors indicate the cancer cell clusters associated with, and the size is proportional to the significance of the association. C 3D Diffusion maps based on the transcription factor activities. The activities of transcription factors in each TF cluster were averaged into a single score and projected onto the 3D diffusion map