Fig. 3

Estimated age of emergence of mmpR5 nonsynonymous/frameshift variants. Inferred point estimates for the age of emergence of clades with mmpR5 variants for the lineage 2 (a) and lineage 4 (b) datasets, including a zoomed-in reproduction of the period from 2007 to 2020. Y-axis provides the absolute number of sequences descending from the identified and dated nodes. The mmpR5 RAV status is given by the colour as defined in the legend at left. *indicates phenotypic data available for considered isolates that are supportive of MIC classification (see text). The full mutation timelines are provided in Additional file 2: Fig S13–S14 and Additional file 3: Table S7