Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis

Table 1 Frequency of all mmpR5 variants occurring ≥ 5 times in dataset and their associated resistance classification. Where co-existing mmpL5 mutations were identified these are indicated

Variant	Associated phenotype	L2	L4	Total
c-11a	Hypersusceptible	93		93
Ile67fs + mmpL5 Arg202fs	Hypersusceptible		65	65
Asp5Gly	Susceptible	20	3	23
Met146Thr	Resistant	2	20	22
Ile67fs	Resistant	5	17	22
Leu40Val	Susceptible		19	19
Arg90Cys	Intermediate	2	9	11
Glu49fs	Resistant	2	8	10
Val20Ala	Intermediate	1	6	7
Ala59Val	Resistant	7		7
Met1Ala	Resistant	6		6
Gly121Arg	Resistant	5	1	6
Asp141fs	Unknown		6	6
Asn98Asp	Resistant		6	6
Arg96Gly	Resistant		5	5
Arg109Leu + Arg156fs	Resistant		5	5

ISSN: 1756-994X