Fig. 5

A, B Genomic landscape of relapsed and refractory childhood solid tumors. The genomic landscape of likely pathogenic driver mutations in 157 subjects with BCC with tumor and matched normal WES. A Mutational signatures are shown as a per-patient bar graph. Chromosome arm-level gains or losses, present in at least 15 subjects within the cohort, are displayed. Cancer genes bearing somatic SNVs, CNVs, SVs, and fusions are ordered according to general tumor type and frequency. B Somatic mutation burden is shown for each general tumor type. C Heatmap of molecular targets (over or under) of top sensitive drugs that are frequently expressed across MGT9 subjects. These drugs are selected based on number of times they are chosen across the subjects (> 10). Rows are divided by drugs, and genes are clustered to find unique or similar expression. Column clustering is performed using 78 genes to find the most similar subjects across different pathologies. Genes are colored with red (over) and blue (under)