NMTRC009 MGT feasibility and safety profile | N = 144 | ||
---|---|---|---|
Started at least one tumor board recommended agent, no. of patients (%) | 144 (100%) | ||
Started 100% of tumor board recommended agents, no. of patients (%) | |||
 Cycle 1 | 121 (84.03%) | ||
 Cycle 2 | 12 (8.33%) | ||
 Cycle 3 | 3 (2.08%) | ||
 Cycle 5 | 1 (0.69%) | ||
 Never | 7 (4.86%) | ||
Cycles, no. of patients (%) | |||
 1 cycle | 19 (13.19%) | ||
 2 cycles | 45 (31.25%) | ||
 3–10 cycles | 57 (39.58%) | ||
  > 10 cycles | 23 (15.97%) | ||
 | Grade 3 | Grade 4 | Grade 5 |
Hematologic toxic effects (related and unexpected), no. of patients (%) | |||
 Anemia |  |  |  |
 Lymphocytopenia |  |  |  |
 Neutropenia |  |  |  |
 Thrombocytopenia |  |  |  |
 Leukopenia | 1 (< 1%) |  |  |
Non-hematologic toxic effects (related and unexpected), no. of patients (%) | |||
 Elevated ALT |  |  |  |
 Elevated AST | 1 (< 1%) | 1 (< 1%) |  |
 Dehydration | 1 (< 1%) |  |  |
 Infection | 2 (< 2%) |  |  |
 Oral mucositis | 1 (< 1%) |  |  |
 Pancreatitis | 1 (< 1%) |  |  |
 | No. of events | No. of patients (%) | |
Cycle 1 toxicity-associated events | |||
 Medication holds | 90 | 45 (31.25%) | |
 Dose reductions | 9 | 9 (6.25%) | |
 Medication discontinuations | 9 | 8 (5.56%) | |
 Cycle delays | 0 | 0 (0%) | |
Cycle 2 toxicity-associated events | |||
 Medication holds | 105 | 52 (41.60%) | |
 Dose reductions | 45 | 31 (24.80%) | |
 Medication discontinuations | 21 | 15 (12.00%) | |
 Cycle delays | 12 | 12 (9.60%) |