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Fig. 1 | Genome Medicine

Fig. 1

From: Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

Fig. 1

Overview of the study. The study was conducted in 17,166 lung cancer cases and 12,894 controls with European ancestry from the International Lung Cancer Consortium (ILCCO). The lung cancer PRSs and corresponding confidence/credible interval were constructed using two statistical approaches for each individual—(1) the weighted sum of 16 GWAS-derived significant SNP loci that have been validated in European descent population and the confidence interval through the bootstrapping method (PRS-16-CV) and (2) LDpred2 and the credible interval through posteriors sampling (PRS-Bayes). The individual-level PRS uncertainty was characterized and the impact on subsequent risk stratification and prediction were evaluated

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Genome Medicine

ISSN: 1756-994X

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