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Table 2 PRS-based rankings identified by PRS-16-CV and PRS-Bayes

From: Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

PRS deciles

PRS-16-CV

PRS-Bayes

n

Mean rankings [range]

n

Mean rankings [range]

0th–10th

751

7th [0th, 66th]

-

34th [0th, 100th]

11th–20th

-

18th [0th, 76th]

-

41st [0th, 100th]

21st–30th

-

28th [1st, 85th]

-

44th [0th, 100th]

31st–40th

-

37th [2nd, 90th]

-

46th [0th, 100th]

41st–50th

-

46th [3rd, 94th]

-

49th [0th, 100th]

51st–60th

-

55th [5th, 97th]

-

51st [0th, 100th]

61st–70th

-

63th [7th, 98th]

-

54th [0th, 100th]

71st–80th

-

72nd [12nd, 99th]

-

56th [0th, 100th]

81st–90th

-

82nd [14th, 100th]

-

60th [0th, 100th]

91st–100th

505

92th [25th, 100th]

-

66th [0th, 100th]

  1. The mean and range of the rankings for each individual within each decile identified by PRS-16-CV and PRS-Bayes were calculated. The column n indicates the number of individuals that can be identified with certainty. Using PRS-16-CV, 751 individuals in the lowest PRS decile and 505 individuals in the highest decile can be identified with certainty. In contrast, PRS-Bayes were not able to identify any individuals with certainty
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Genome Medicine

ISSN: 1756-994X

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