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Table 4 Impact of individual-level uncertainty on relative risk of PRS deciles on lung cancer risk

From: Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

PRS deciles

PRS CI-based risk stratification

PRS mean-based risk stratification

OR (95% CI)

P-value

n

OR (95% CI)

P-value

n

0th–10th

1 (reference group)

-

751

1 (reference group)

 

3006

11th–20th

-

-

 

1.15 (1.04, 1.29)

8.80e−03

3006

21st–30th

-

-

 

1.31 (1.17, 1.45)

9.70e−07

3006

31st–40th

-

-

 

1.31 (1.18, 1.46)

6.70e−07

3006

41st–50th

-

-

 

1.44(1.30, 1.61)

2.40e−11

3006

51st–60th

-

-

 

1.54 (1.39, 1.72)

3.00e−15

3006

61st–70th

-

-

 

1.55 (1.39, 1.72)

2.00e−15

3006

71st–80th

-

-

 

1.80 (1.61, 2.01)

3.60e−26

3006

81st–90th

-

-

 

1.76 (1.58, 1.96)

2.40e−24

3006

91st–100th

2.73 (2.12, 3.50)

4.13e−15

505

2.23 (1.99, 2.49)

5.70e−46

3006

  1. Odds ratio of lung cancer comparing different PRS deciles identified by PRS CI-based approach taking individual level uncertainty into account and by PRS mean were shown. As the PRS-16-CV CI-based approach was only able to identify individuals in the lowest (n = 751) and highest decile (n = 505) with certainty, the analysis was only conducted in the two subsets. In contrast, using the PRS-16-CV mean, the analyses were conducted in each PRS decile compared to the lowest one. The detailed sample sizes that were included in each analysis were noted in column n. Odds ratio (OR) and 95% confidence intervals (CI) are shown. All models were adjusted for age, gender, and smoking status