PRS deciles | PRS CI-based risk stratification | PRS mean-based risk stratification |
---|
OR (95% CI) | P-value | n | OR (95% CI) | P-value | n |
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0th–10th | 1 (reference group) | - | 751 | 1 (reference group) | | 3006 |
11th–20th | - | - | | 1.15 (1.04, 1.29) | 8.80e−03 | 3006 |
21st–30th | - | - | | 1.31 (1.17, 1.45) | 9.70e−07 | 3006 |
31st–40th | - | - | | 1.31 (1.18, 1.46) | 6.70e−07 | 3006 |
41st–50th | - | - | | 1.44(1.30, 1.61) | 2.40e−11 | 3006 |
51st–60th | - | - | | 1.54 (1.39, 1.72) | 3.00e−15 | 3006 |
61st–70th | - | - | | 1.55 (1.39, 1.72) | 2.00e−15 | 3006 |
71st–80th | - | - | | 1.80 (1.61, 2.01) | 3.60e−26 | 3006 |
81st–90th | - | - | | 1.76 (1.58, 1.96) | 2.40e−24 | 3006 |
91st–100th | 2.73 (2.12, 3.50) | 4.13e−15 | 505 | 2.23 (1.99, 2.49) | 5.70e−46 | 3006 |
- Odds ratio of lung cancer comparing different PRS deciles identified by PRS CI-based approach taking individual level uncertainty into account and by PRS mean were shown. As the PRS-16-CV CI-based approach was only able to identify individuals in the lowest (n = 751) and highest decile (n = 505) with certainty, the analysis was only conducted in the two subsets. In contrast, using the PRS-16-CV mean, the analyses were conducted in each PRS decile compared to the lowest one. The detailed sample sizes that were included in each analysis were noted in column n. Odds ratio (OR) and 95% confidence intervals (CI) are shown. All models were adjusted for age, gender, and smoking status