Table 5 Impact of individual-level uncertainty on the relative risk of PRS deciles on lung cancer risk in stratified analyses by gender, lung cancer histology, and smoking status

Gender

Male

2.63 (1.91, 3.62)

3.09e−09

772

2.06 (1.79, 2.37)

2.80e−24

3731

Female

2.88 (1.92, 4.32)

2.83e−07

484

2.54 (2.12, 3.04)

3.39e−24

2281

Histology

NSCLC

2.84 (2.19, 3.70)

6.14e−15

1117

2.31 (2.06, 2.60)

3.53e−45

5199

ADC

3.70 (2.69, 5.09)

8.71e−16

842

2.76 (2.39, 3.18)

9.60e−45

3874

SCC

2.11 (1.45, 3.07)

8.93e−05

752

1.71 (1.45, 2.02)

2.61e−10

3406

SCLC

2.53 (1.43, 4.46)

1.38e−03

630

1.86 (1.47, 2.36)

2.01e−07

2906

Smoking

Never

4.22 (2.25, 7.92)

7.25e−06

223

2.63 (2.02, 3.43)

9.94e−13

1125

Former

2.25 (1.54, 3.28)

2.43e−05

494

2.18 (1.83, 2.59)

1.19e−18

2280

Current

2.74 (1.84, 4.10)

8.28e−07

539

2.13 (1.79, 2.52)

3.88e−18

2607