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Fig. 6 | Genome Medicine

Fig. 6

From: Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes

Fig. 6

Cell type-specific DEGs enriched for T1DM genetic risk. a Significance of association between cell type-specific DEGs and T1DM risk loci. Upper panel: entire genome, lower panel: non-HLA loci. FDR q-values: Benjamini-Hochberg correction. b Heatmap of cell type-specific differential expression score (DES) of genes in T1DM GWAS loci. Gene within the upper 30th percentile of DES that also rank within top 200 in the genome by T1DM genetic risk score are shown. Genetic risk scores [\(-log10\) (MAGMA p-value)] of individual genes are shown by the bar plot on the right. Black: DEGs, gray: upstream transcription factors inferred by regulon analysis

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Genome Medicine

ISSN: 1756-994X

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