Fig. 5

scDrugPrio applied to scRNA-seq data from cerebrospinal fluid samples of MS patients and controls. a, b Clustering and cell type proportions (%) for CSF samples of idiopathic intracranial hypertension (IIH) and multiple sclerosis patients (MS). Cell type proportions showed significant interindividual differences among MS patients. c The MCDM for MS was more complex than that of AIA mice. The most central cells included mononuclear phagocyte 3, natural killer cells, mononuclear phagocyte 2, early activated CD8 + T cells and plasma B-cells (in order of eigenvector centrality). d Precision among ranked candidates for approved MS drugs, drugs that had been registered for clinical trials for MS in the ClinicalTrial.database, and literature evidence (only for top 100 ranking drugs). Abbreviations: Tm, T memory; Tem, T effector memory