Fig. 2

Tumor cells in PitNETs can be divided into three lineages based on their gene expression profile. A Gene expression patterns and clinical features of three distinct lineages in PitNETs. The columns represent PitNET patients, and the rows indicate gene expression levels or clinical features. B Bubble diagram illustrating the Gene Ontology (GO) biological processes (BP) associated with the three distinct tumor lineages. C Heatmap displaying the activation level of TF and their expression in the three PitNET lineages, as determined by scRNA-seq and bulk RNA-seq methods