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Fig. 4 | Genome Medicine

Fig. 4

From: Clustering of predicted loss-of-function variants in genes linked with monogenic disease can explain incomplete penetrance

Fig. 4

Proportions of genes in clusters 4–6 in UKB compared with simulations. The proportion of genes where pLoFs in the UK Biobank are clustered into clusters 4–6 against the number of pLoFs in that gene is shown in blue. The proportion of simulated genes where pLoFs clustered into clusters 4–6 against the number of variants in the gene is shown in red. The green line shows the number of genes with each number of pLoFs in UK Biobank. The X-axis is log10-transformed

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Genome Medicine

ISSN: 1756-994X

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