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Fig. 2 | Genome Medicine

Fig. 2

From: Polygenic scores for longitudinal prediction of incident type 2 diabetes in an ancestrally and medically diverse primary care physician network: a patient cohort study

Fig. 2

Kaplan-Meier curves with and without stratification by baseline clinical risk factors. T2D PGS tertiles show strong separation of T2D onset in (A) scenario 1, (B) scenario 2, (C) scenario 3, and (D) scenario 4. In each scenario, the multivariate log-rank test was P < 0.0001. T2D PGS tertiles further stratify risk over available clinical risk factors at each scenario, including (E) an age cutoff of 40 years in scenario 1, (F) a BMI cutoff of 27.5 kg/m2 in scenario 2, (G) a random glucose of 100 mg/dL in scenario 3, and (H) the median T2D CRS in scenario 4. In each stratification analysis per scenario, the multivariate log-rank test was P < 0.0001

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Genome Medicine

ISSN: 1756-994X

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