Cytokine/hormone | IVW Fixed effects | IVW Random effects | Heterogeneity statistics | |||
OR (95% CI) | P-value | OR (95% CI) | P-value | IVW Cochran’s Q (P-value) | IVW I2 | |
Adipsin | 1.74 (1.44, 2.11) | 8.46 × 10−9 | 1.74 (0.93, 3.26) | 0.081 | 21.81 (< 0.001) | 90.8 |
Leptin | 1.20 (0.73, 1.97) | 0.470 | 1.20 (0.73, 1.97) | 0.470 | 0.95 (0.330) | 0.0 |
Visfatin | 1.33 (0.87, 2.03) | 0.181 | 1.33 (0.87, 2.03) | 0.181 | 0.92 (0.338) | 0.0 |
PAI-1 | 0.77 (0.53, 1.13) | 0.185 | 0.77 (0.53, 1.13) | 0.185 | 0.62 (0.735) | 0.0 |
GIP | 1.24 (0.96, 1.60) | 0.104 | 1.24 (0.96, 1.60) | 0.104 | 2.54 (0.864) | 0.0 |
GLP-1 | 0.83 (0.54, 1.27) | 0.391 | 0.83 (0.52, 1.34) | 0.444 | 2.51 (0.285) | 20.3 |
Ghrelin | 1.09 (0.77, 1.56) | 0.624 | 1.09 (0.65, 1.84) | 0.738 | 2.15 (0.143) | 53.5 |
Resistin | 1.02 (0.89, 1.16) | 0.821 | 1.02 (0.89, 1.16) | 0.823 | 6.13 (0.409) | 2.1 |
IL-6 | 1.19 (0.86, 1.65) | 0.288 | 1.19 (0.86, 1.65) | 0.288 | NA | NA |
IL-10 | 1.01 (0.82, 1.25) | 0.903 | 1.01 (0.75, 1.37) | 0.931 | 1.98 (0.159) | 49.5 |
IL-1RA | 1.00 (0.81, 1.25) | 0.965 | 1.00 (0.63, 1.61) | 0.984 | 9.18 (0.010) | 78.2 |
Median | MR-Egger | Heterogeneity statistics | ||||
OR (95% CI) | P-value | OR (95% CI) | P-value | MR-Egger Intercept (P-value) | MR-Egger I2 | |
Adipsin | 1.74 (1.40, 2.17) | 6.81 × 10−7 | 3.44 (0.81, 14.53) | 0.093 | − 0.225 (0.306) | 97.0 |
Leptin | NA | NA | ||||
Visfatin | NA | NA | ||||
PAI-1 | 0.76 (0.48, 1.20) | 0.237 | 0.41 (0.08, 2.06) | 0.281 | 0.193 (0.433) | 0.0 |
GIP | 1.37 (0.98, 1.90) | 0.062 | 1.41 (0.92, 2.14) | 0.111 | − 0.040 (0.446) | 0.0 |
GLP-1 | 1.04 (0.59, 1.81) | 0.894 | 0.30 (0.07, 1.29) | 0.107 | 0.226 (0.155) | 0.0 |
Ghrelin | NA | NA | ||||
Resistin | 1.03 (0.88, 1.20) | 0.709 | 1.27 (0.93, 1.73) | 0.131 | − 0.108 (0.118) | 95.2 |
IL-6 | NA | NA | ||||
IL-10 | NA | NA | ||||
IL-1RA | 1.08 (0.79, 1.49) | 0.621 | 2.52 (1.24, 5.12) | 0.010 | − 0.384 (0.007) | 0.0 |