TY - JOUR AU - Vasta, Valeria AU - Ng, Sarah B. AU - Turner, Emily H. AU - Shendure, Jay AU - Hahn, Si Houn PY - 2009 DA - 2009/10/23 TI - Next generation sequence analysis for mitochondrial disorders JO - Genome Medicine SP - 100 VL - 1 IS - 10 AB - Mitochondrial disorders can originate from mutations in one of many nuclear genes controlling the organelle function or in the mitochondrial genome (mitochondrial DNA (mtDNA)). The large numbers of potential culprit genes, together with the little guidance offered by most clinical phenotypes as to which gene may be causative, are a great challenge for the molecular diagnosis of these disorders. SN - 1756-994X UR - https://doi.org/10.1186/gm100 DO - 10.1186/gm100 ID - Vasta2009 ER -