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Figure 3 | Genome Medicine

Figure 3

From: Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/obmouse

Figure 3

Multivariate analysis of the changes in intact lipid metabolism induced by stimulation of PPARδ and PPARγ. (a) PLS-DA scores plot showing the clustering of the UPLC-MS chromatograms from the organic fraction of liver tissue from mice treated with a PPARδ agonist compared with control mice. Circle, PPARδ agonist treated; square, control (R2 = 0.88, Q2 = 0.57) (b) PLS-DA scores plot showing the clustering of the UPLC-MS chromatograms from the organic fraction of liver tissue from mice treated with a PPARγ agonist compared with control mice. Diamond, PPARγ agonist treated; square, control (R2 = 1.00, Q2 = 0.85). (c) PLS-DA scores plot showing the clustering of the UPLC-MS chromatograms from the organic fraction of serum from mice treated with a PPARδ agonist compared with control mice. Circle, PPARδ agonist treated; square, control (R2 = 0.95, Q2 = 0.82). (d) PLS-DA scores plot showing the clustering of the UPLC-MS chromatograms from the organic fraction of serum from mice treated with a PPARγ agonist compared with control mice. Diamond, PPARγ agonist treated; square, control (R2 = 0.99, Q2 = 0.86).

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