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Figure 4 | Genome Medicine

Figure 4

From: Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/obmouse

Figure 4

Multivariate analysis of some of the key metabolic changes induced by PPARδ stimulation. (a) PLS-DA scores plot showing the clustering of the GC-MS chromatograms from the organic fraction of liver tissue from mice treated with a PPARδ agonist compared with control mice. Circle, PPARδ agonist treated; square, control (R2 = 0.43, Q2 = 0.82). (b) PLS-DA scores plot showing the clustering of the GC-MS chromatograms from the aqueous extracts from skeletal muscle from mice treated with a PPARδ agonist compared with control mice. Circle, PPARδ agonist treated; square, control (R2 = 0.69, Q2 = 0.73). (c) Comparison of the region of typical GC-MS chromatograms of control skeletal muscle tissue (black) and skeletal muscle tissue from mice treated with a PPARδ agonist (gray) containing the serine peak. (d) Bar graph demonstrating the difference in the average integrated area of the serine peak from control and PPARδ agonist treated liver. Error bars show standard error deviations from the mean. *P < 0.05 with respect to vehicle control animals.

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Genome Medicine

ISSN: 1756-994X

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