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Table 2 Gene ontology classification of proteins with statistically significant changes (FDR < 0.01) for E+P or E-alone

From: Postmenopausal estrogen and progestin effects on the serum proteome

  

E+P

E-Alone

Protein

Description

Log2 ratio year 1 relative to baseline

Pvalue

FDR

Log2 ratio year 1 relative to baseline

Pvalue

FDR

Blood coagulation and inflammation

VTN

Vitronectin

0.352

2.16E-07

2.68E-05

0.368

7.09E-08

8.98E-06

CP

Ceruloplasmin

0.679

5.19E-07

2.87E-05

0.752

3.01E-07

2.86E-05

SERPINC1

Antithrombin III variant

-0.196

5.05E-06

0.000157

-0.143

5.50E-05

0.00106

PLG

Plasminogen

0.224

1.56E-05

0.000404

0.230

1.24E-05

0.000393

HABP2

Uncharacterized protein

0.251

5.23E-05

0.00108

0.309

7.24E-05

0.00131

F12

Coagulation factor XII

0.261

0.000102

0.00158

0.252

0.000219

0.00268

APOH

β2- Glycoprotein 1

0.149

0.000199

0.00242

0.193

8.89E-05

0.00135

ATRN

Attractin

-0.190

0.000213

0.00242

-0.126

0.00366

0.0214

F9

Coagulation factor IX

0.540

0.000214

0.00242

0.572

0.000511

0.00498

TFPI

Tissue factor pathway inhibitor

-0.396

0.000315

0.00317

-0.369

8.49E-05

0.00135

KNG1

Kininogen-1

0.152

0.00106

0.00786

0.228

5.60E-05

0.00106

Metabolism

       

GC

Vitamin D-binding protein

0.231

3.10E-06

0.000115

0.237

2.75E-06

0.000131

HPX

Hemopexin

0.123

6.65E-05

0.00118

0.117

0.000124

0.00162

RBP4

Plasma retinol-binding protein

0.167

0.000117

0.00161

0.177

0.000262

0.00311

APOA2

Apolipoprotein A-II

0.212

0.000532

0.00483

0.302

1.75E-05

0.000475

ENPP2

Ectonucleotide Pyrophosphatase/phosphodiesterase family member 2

0.369

0.00692

0.0333

0.650

0.000749

0.00619

Osteogenesis

       

FETUB

Fetuin-B

0.783

1.09E-09

4.04E-07

0.741

1.02E-09

3.89E-07

COL1A1

Collagen α-1(I) chain

-0.896

5.40E-07

2.87E-05

-0.575

8.80E-05

0.00135

AHSG

α2- HS-glycoprotein

0.211

3.44E-06

0.000116

0.243

7.46E-07

5.02E-05

NOTCH2

Neurogenic locus notch homologue protein 2

-0.784

0.000315

0.00317

-0.062

0.648

0.815

Complement and immune response

PGLYRP2

N-acetylmuramoyl-L-alanine amidase

-0.343

1.49E-06

6.17E-05

-0.335

3.72E-06

0.000141

ORM2

α1- acid glycoprotein 2

-0.181

1.63E-05

0.000404

-0.144

8.38E-05

0.00135

C4BPA

C4B-binding protein α chain

-0.200

3.34E-05

0.000731

-0.148

0.000377

0.00398

CFHR1

Complement factor H-related protein 1

0.162

8.95E-05

0.00145

0.185

2.96E-05

0.000661

CFB

Complement factor B

0.137

0.000106

0.00158

0.210

5.58E-06

0.000193

C8A

Complement component C8 α chain

-0.206

0.000163

0.00216

-0.202

0.000121

0.00162

C4BPB

C4B-binding protein β chain

-0.260

0.00018

0.0023

-0.196

0.00156

0.0112

PGLYRP1

Peptidoglycan recognition protein

0.321

0.000232

0.00253

-0.056

0.458

0.68

CFHR5

Complement factor H-related 5

0.179

0.000264

0.00281

0.241

2.76E-05

0.000656

MASP2

Mannan-binding lectin serine protease 2

0.200

0.000435

0.00415

0.173

0.000643

0.00568

CFHR2

Complement factor H-related protein 2

0.181

0.000449

0.00417

0.205

0.00016

0.00203

C8B

Complement component C8 β chain

-0.221

0.00059

0.00522

-0.199

0.0015

0.0112

ITIH4

Inter-α-trypsin inhibitor heavy chain H4

0.458

0.000733

0.00634

0.374

0.00495

0.0273

VNN1

Pantetheinase

0.477

0.000888

0.00688

0.517

0.00124

0.00963

C6

complement component C6

-0.123

0.00151

0.011

-0.171

0.000123

0.00162

B2M

β2- microglobulin

0.208

0.00205

0.0144

0.230

0.0011

0.00873

LRG1

Leucine-rich α2-glycoprotein

0.278

0.00553

0.0278

0.445

0.000582

0.0054

MBL2

Mannose-binding protein C

-0.190

0.00677

0.0331

-0.341

9.37E-05

0.00137

LILRA3

Leukocyte immunoglobulin-like receptor subfamily A member 3

-0.237

0.00874

0.0374

-0.281

0.000277

0.00319

FN1

Fibronectin

-0.193

0.0663

0.176

-0.358

0.000574

0.0054

Cell adhesion

ICAM1

Intercellular adhesion molecule 1

-0.299

2.69E-05

0.000626

-0.142

0.00171

0.012

MEGF10

Multiple epidermal growth factor-like domains 10

-1.330

0.0365

0.114

-1.100

0.000671

0.0058

Growth factor activity

IGFBP7

Insulin-like growth factor-binding protein 7

-0.295

0.000404

0.00395

-0.133

0.0342

0.109

NOV

Protein NOV homologue

-0.759

0.00083

0.00672

-0.344

0.0123

0.0506

IGF1

Insulin-like growth factor IA

-0.353

0.000981

0.00745

-0.371

0.000403

0.00414

IGFBP1

Insulin-like growth factor-binding protein 1

0.528

0.00242

0.0158

1.270

3.66E-06

0.000141

IGFBP4

Insulin-like growth factor-binding protein 4

0.179

0.102

0.234

0.511

0.000697

0.00588

Other

       

SHBG

Sex hormone-binding globulin

1.460

1.14E-08

2.13E-06

1.450

2.57E-08

4.88E-06

AGT

Angiotensinogen

1.150

3.09E-07

2.87E-05

1.200

2.05E-06

0.000111

LUM

Lumican

-0.382

4.81E-07

2.87E-05

-0.163

0.00175

0.0121

TFF3

Trefoil factor 3

2.590

8.84E-07

4.11E-05

2.160

2.06E-05

0.000522

OAF

Out at first protein homologue

0.398

7.32E-06

0.000209

0.393

4.17E-05

0.000881

A1BG

α1B-Glycoprotein

0.167

5.71E-05

0.00112

0.266

7.92E-07

5.02E-05

ABI3BP

Target of NESH-SH3

-0.290

6.07E-05

0.00113

-0.184

0.00149

0.0112

CLEC3B

Tetranectin

-0.240

7.65E-05

0.00129

-0.158

0.00102

0.00827

FBN1

Fibrillin-1

-0.365

0.000114

0.00161

-0.269

1.45E-05

0.000423

DBH

Dopamine β-hydroxylase

-0.262

0.000207

0.00242

-0.186

0.00203

0.013

FGA

Fibrinogen α chain

0.364

0.00076

0.00643

0.303

0.00741

0.0373

SPARCL1

SPARC-like protein 1

-0.311

0.0008

0.00661

-0.043

0.508

0.722

CPN2

Carboxypeptidase N subunit 2

0.161

0.000865

0.00685

0.190

0.000331

0.0036

AMBP

AMBP protein

0.116

0.00283

0.0174

0.148

0.00061

0.00552

PEAR1

Platelet endothelial aggregation receptor 1

-0.650

0.00948

0.0379

-0.722

0.000424

0.00424

AFM

Afamin

0.058

0.119

0.259

0.177

0.00033

0.0036

  1. P value = significance level for test of no change in protein concentration; FDR = estimated false discovery rate for this test.