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Table 2 Gene ontology classification of proteins with statistically significant changes (FDR < 0.01) for E+P or E-alone

From: Postmenopausal estrogen and progestin effects on the serum proteome

   E+P E-Alone
Protein Description Log2 ratio year 1 relative to baseline Pvalue FDR Log2 ratio year 1 relative to baseline Pvalue FDR
Blood coagulation and inflammation
VTN Vitronectin 0.352 2.16E-07 2.68E-05 0.368 7.09E-08 8.98E-06
CP Ceruloplasmin 0.679 5.19E-07 2.87E-05 0.752 3.01E-07 2.86E-05
SERPINC1 Antithrombin III variant -0.196 5.05E-06 0.000157 -0.143 5.50E-05 0.00106
PLG Plasminogen 0.224 1.56E-05 0.000404 0.230 1.24E-05 0.000393
HABP2 Uncharacterized protein 0.251 5.23E-05 0.00108 0.309 7.24E-05 0.00131
F12 Coagulation factor XII 0.261 0.000102 0.00158 0.252 0.000219 0.00268
APOH β2- Glycoprotein 1 0.149 0.000199 0.00242 0.193 8.89E-05 0.00135
ATRN Attractin -0.190 0.000213 0.00242 -0.126 0.00366 0.0214
F9 Coagulation factor IX 0.540 0.000214 0.00242 0.572 0.000511 0.00498
TFPI Tissue factor pathway inhibitor -0.396 0.000315 0.00317 -0.369 8.49E-05 0.00135
KNG1 Kininogen-1 0.152 0.00106 0.00786 0.228 5.60E-05 0.00106
Metabolism        
GC Vitamin D-binding protein 0.231 3.10E-06 0.000115 0.237 2.75E-06 0.000131
HPX Hemopexin 0.123 6.65E-05 0.00118 0.117 0.000124 0.00162
RBP4 Plasma retinol-binding protein 0.167 0.000117 0.00161 0.177 0.000262 0.00311
APOA2 Apolipoprotein A-II 0.212 0.000532 0.00483 0.302 1.75E-05 0.000475
ENPP2 Ectonucleotide Pyrophosphatase/phosphodiesterase family member 2 0.369 0.00692 0.0333 0.650 0.000749 0.00619
Osteogenesis        
FETUB Fetuin-B 0.783 1.09E-09 4.04E-07 0.741 1.02E-09 3.89E-07
COL1A1 Collagen α-1(I) chain -0.896 5.40E-07 2.87E-05 -0.575 8.80E-05 0.00135
AHSG α2- HS-glycoprotein 0.211 3.44E-06 0.000116 0.243 7.46E-07 5.02E-05
NOTCH2 Neurogenic locus notch homologue protein 2 -0.784 0.000315 0.00317 -0.062 0.648 0.815
Complement and immune response
PGLYRP2 N-acetylmuramoyl-L-alanine amidase -0.343 1.49E-06 6.17E-05 -0.335 3.72E-06 0.000141
ORM2 α1- acid glycoprotein 2 -0.181 1.63E-05 0.000404 -0.144 8.38E-05 0.00135
C4BPA C4B-binding protein α chain -0.200 3.34E-05 0.000731 -0.148 0.000377 0.00398
CFHR1 Complement factor H-related protein 1 0.162 8.95E-05 0.00145 0.185 2.96E-05 0.000661
CFB Complement factor B 0.137 0.000106 0.00158 0.210 5.58E-06 0.000193
C8A Complement component C8 α chain -0.206 0.000163 0.00216 -0.202 0.000121 0.00162
C4BPB C4B-binding protein β chain -0.260 0.00018 0.0023 -0.196 0.00156 0.0112
PGLYRP1 Peptidoglycan recognition protein 0.321 0.000232 0.00253 -0.056 0.458 0.68
CFHR5 Complement factor H-related 5 0.179 0.000264 0.00281 0.241 2.76E-05 0.000656
MASP2 Mannan-binding lectin serine protease 2 0.200 0.000435 0.00415 0.173 0.000643 0.00568
CFHR2 Complement factor H-related protein 2 0.181 0.000449 0.00417 0.205 0.00016 0.00203
C8B Complement component C8 β chain -0.221 0.00059 0.00522 -0.199 0.0015 0.0112
ITIH4 Inter-α-trypsin inhibitor heavy chain H4 0.458 0.000733 0.00634 0.374 0.00495 0.0273
VNN1 Pantetheinase 0.477 0.000888 0.00688 0.517 0.00124 0.00963
C6 complement component C6 -0.123 0.00151 0.011 -0.171 0.000123 0.00162
B2M β2- microglobulin 0.208 0.00205 0.0144 0.230 0.0011 0.00873
LRG1 Leucine-rich α2-glycoprotein 0.278 0.00553 0.0278 0.445 0.000582 0.0054
MBL2 Mannose-binding protein C -0.190 0.00677 0.0331 -0.341 9.37E-05 0.00137
LILRA3 Leukocyte immunoglobulin-like receptor subfamily A member 3 -0.237 0.00874 0.0374 -0.281 0.000277 0.00319
FN1 Fibronectin -0.193 0.0663 0.176 -0.358 0.000574 0.0054
Cell adhesion
ICAM1 Intercellular adhesion molecule 1 -0.299 2.69E-05 0.000626 -0.142 0.00171 0.012
MEGF10 Multiple epidermal growth factor-like domains 10 -1.330 0.0365 0.114 -1.100 0.000671 0.0058
Growth factor activity
IGFBP7 Insulin-like growth factor-binding protein 7 -0.295 0.000404 0.00395 -0.133 0.0342 0.109
NOV Protein NOV homologue -0.759 0.00083 0.00672 -0.344 0.0123 0.0506
IGF1 Insulin-like growth factor IA -0.353 0.000981 0.00745 -0.371 0.000403 0.00414
IGFBP1 Insulin-like growth factor-binding protein 1 0.528 0.00242 0.0158 1.270 3.66E-06 0.000141
IGFBP4 Insulin-like growth factor-binding protein 4 0.179 0.102 0.234 0.511 0.000697 0.00588
Other        
SHBG Sex hormone-binding globulin 1.460 1.14E-08 2.13E-06 1.450 2.57E-08 4.88E-06
AGT Angiotensinogen 1.150 3.09E-07 2.87E-05 1.200 2.05E-06 0.000111
LUM Lumican -0.382 4.81E-07 2.87E-05 -0.163 0.00175 0.0121
TFF3 Trefoil factor 3 2.590 8.84E-07 4.11E-05 2.160 2.06E-05 0.000522
OAF Out at first protein homologue 0.398 7.32E-06 0.000209 0.393 4.17E-05 0.000881
A1BG α1B-Glycoprotein 0.167 5.71E-05 0.00112 0.266 7.92E-07 5.02E-05
ABI3BP Target of NESH-SH3 -0.290 6.07E-05 0.00113 -0.184 0.00149 0.0112
CLEC3B Tetranectin -0.240 7.65E-05 0.00129 -0.158 0.00102 0.00827
FBN1 Fibrillin-1 -0.365 0.000114 0.00161 -0.269 1.45E-05 0.000423
DBH Dopamine β-hydroxylase -0.262 0.000207 0.00242 -0.186 0.00203 0.013
FGA Fibrinogen α chain 0.364 0.00076 0.00643 0.303 0.00741 0.0373
SPARCL1 SPARC-like protein 1 -0.311 0.0008 0.00661 -0.043 0.508 0.722
CPN2 Carboxypeptidase N subunit 2 0.161 0.000865 0.00685 0.190 0.000331 0.0036
AMBP AMBP protein 0.116 0.00283 0.0174 0.148 0.00061 0.00552
PEAR1 Platelet endothelial aggregation receptor 1 -0.650 0.00948 0.0379 -0.722 0.000424 0.00424
AFM Afamin 0.058 0.119 0.259 0.177 0.00033 0.0036
  1. P value = significance level for test of no change in protein concentration; FDR = estimated false discovery rate for this test.