From: Postmenopausal estrogen and progestin effects on the serum proteome
 |  | E+P | E-Alone | ||||
---|---|---|---|---|---|---|---|
Protein | Description | Log2 ratio year 1 relative to baseline | Pvalue | FDR | Log2 ratio year 1 relative to baseline | Pvalue | FDR |
Blood coagulation and inflammation | |||||||
VTN | Vitronectin | 0.352 | 2.16E-07 | 2.68E-05 | 0.368 | 7.09E-08 | 8.98E-06 |
CP | Ceruloplasmin | 0.679 | 5.19E-07 | 2.87E-05 | 0.752 | 3.01E-07 | 2.86E-05 |
SERPINC1 | Antithrombin III variant | -0.196 | 5.05E-06 | 0.000157 | -0.143 | 5.50E-05 | 0.00106 |
PLG | Plasminogen | 0.224 | 1.56E-05 | 0.000404 | 0.230 | 1.24E-05 | 0.000393 |
HABP2 | Uncharacterized protein | 0.251 | 5.23E-05 | 0.00108 | 0.309 | 7.24E-05 | 0.00131 |
F12 | Coagulation factor XII | 0.261 | 0.000102 | 0.00158 | 0.252 | 0.000219 | 0.00268 |
APOH | β2- Glycoprotein 1 | 0.149 | 0.000199 | 0.00242 | 0.193 | 8.89E-05 | 0.00135 |
ATRN | Attractin | -0.190 | 0.000213 | 0.00242 | -0.126 | 0.00366 | 0.0214 |
F9 | Coagulation factor IX | 0.540 | 0.000214 | 0.00242 | 0.572 | 0.000511 | 0.00498 |
TFPI | Tissue factor pathway inhibitor | -0.396 | 0.000315 | 0.00317 | -0.369 | 8.49E-05 | 0.00135 |
KNG1 | Kininogen-1 | 0.152 | 0.00106 | 0.00786 | 0.228 | 5.60E-05 | 0.00106 |
Metabolism | Â | Â | Â | Â | Â | Â | Â |
GC | Vitamin D-binding protein | 0.231 | 3.10E-06 | 0.000115 | 0.237 | 2.75E-06 | 0.000131 |
HPX | Hemopexin | 0.123 | 6.65E-05 | 0.00118 | 0.117 | 0.000124 | 0.00162 |
RBP4 | Plasma retinol-binding protein | 0.167 | 0.000117 | 0.00161 | 0.177 | 0.000262 | 0.00311 |
APOA2 | Apolipoprotein A-II | 0.212 | 0.000532 | 0.00483 | 0.302 | 1.75E-05 | 0.000475 |
ENPP2 | Ectonucleotide Pyrophosphatase/phosphodiesterase family member 2 | 0.369 | 0.00692 | 0.0333 | 0.650 | 0.000749 | 0.00619 |
Osteogenesis | Â | Â | Â | Â | Â | Â | Â |
FETUB | Fetuin-B | 0.783 | 1.09E-09 | 4.04E-07 | 0.741 | 1.02E-09 | 3.89E-07 |
COL1A1 | Collagen α-1(I) chain | -0.896 | 5.40E-07 | 2.87E-05 | -0.575 | 8.80E-05 | 0.00135 |
AHSG | α2- HS-glycoprotein | 0.211 | 3.44E-06 | 0.000116 | 0.243 | 7.46E-07 | 5.02E-05 |
NOTCH2 | Neurogenic locus notch homologue protein 2 | -0.784 | 0.000315 | 0.00317 | -0.062 | 0.648 | 0.815 |
Complement and immune response | |||||||
PGLYRP2 | N-acetylmuramoyl-L-alanine amidase | -0.343 | 1.49E-06 | 6.17E-05 | -0.335 | 3.72E-06 | 0.000141 |
ORM2 | α1- acid glycoprotein 2 | -0.181 | 1.63E-05 | 0.000404 | -0.144 | 8.38E-05 | 0.00135 |
C4BPA | C4B-binding protein α chain | -0.200 | 3.34E-05 | 0.000731 | -0.148 | 0.000377 | 0.00398 |
CFHR1 | Complement factor H-related protein 1 | 0.162 | 8.95E-05 | 0.00145 | 0.185 | 2.96E-05 | 0.000661 |
CFB | Complement factor B | 0.137 | 0.000106 | 0.00158 | 0.210 | 5.58E-06 | 0.000193 |
C8A | Complement component C8 α chain | -0.206 | 0.000163 | 0.00216 | -0.202 | 0.000121 | 0.00162 |
C4BPB | C4B-binding protein β chain | -0.260 | 0.00018 | 0.0023 | -0.196 | 0.00156 | 0.0112 |
PGLYRP1 | Peptidoglycan recognition protein | 0.321 | 0.000232 | 0.00253 | -0.056 | 0.458 | 0.68 |
CFHR5 | Complement factor H-related 5 | 0.179 | 0.000264 | 0.00281 | 0.241 | 2.76E-05 | 0.000656 |
MASP2 | Mannan-binding lectin serine protease 2 | 0.200 | 0.000435 | 0.00415 | 0.173 | 0.000643 | 0.00568 |
CFHR2 | Complement factor H-related protein 2 | 0.181 | 0.000449 | 0.00417 | 0.205 | 0.00016 | 0.00203 |
C8B | Complement component C8 β chain | -0.221 | 0.00059 | 0.00522 | -0.199 | 0.0015 | 0.0112 |
ITIH4 | Inter-α-trypsin inhibitor heavy chain H4 | 0.458 | 0.000733 | 0.00634 | 0.374 | 0.00495 | 0.0273 |
VNN1 | Pantetheinase | 0.477 | 0.000888 | 0.00688 | 0.517 | 0.00124 | 0.00963 |
C6 | complement component C6 | -0.123 | 0.00151 | 0.011 | -0.171 | 0.000123 | 0.00162 |
B2M | β2- microglobulin | 0.208 | 0.00205 | 0.0144 | 0.230 | 0.0011 | 0.00873 |
LRG1 | Leucine-rich α2-glycoprotein | 0.278 | 0.00553 | 0.0278 | 0.445 | 0.000582 | 0.0054 |
MBL2 | Mannose-binding protein C | -0.190 | 0.00677 | 0.0331 | -0.341 | 9.37E-05 | 0.00137 |
LILRA3 | Leukocyte immunoglobulin-like receptor subfamily A member 3 | -0.237 | 0.00874 | 0.0374 | -0.281 | 0.000277 | 0.00319 |
FN1 | Fibronectin | -0.193 | 0.0663 | 0.176 | -0.358 | 0.000574 | 0.0054 |
Cell adhesion | |||||||
ICAM1 | Intercellular adhesion molecule 1 | -0.299 | 2.69E-05 | 0.000626 | -0.142 | 0.00171 | 0.012 |
MEGF10 | Multiple epidermal growth factor-like domains 10 | -1.330 | 0.0365 | 0.114 | -1.100 | 0.000671 | 0.0058 |
Growth factor activity | |||||||
IGFBP7 | Insulin-like growth factor-binding protein 7 | -0.295 | 0.000404 | 0.00395 | -0.133 | 0.0342 | 0.109 |
NOV | Protein NOV homologue | -0.759 | 0.00083 | 0.00672 | -0.344 | 0.0123 | 0.0506 |
IGF1 | Insulin-like growth factor IA | -0.353 | 0.000981 | 0.00745 | -0.371 | 0.000403 | 0.00414 |
IGFBP1 | Insulin-like growth factor-binding protein 1 | 0.528 | 0.00242 | 0.0158 | 1.270 | 3.66E-06 | 0.000141 |
IGFBP4 | Insulin-like growth factor-binding protein 4 | 0.179 | 0.102 | 0.234 | 0.511 | 0.000697 | 0.00588 |
Other | Â | Â | Â | Â | Â | Â | Â |
SHBG | Sex hormone-binding globulin | 1.460 | 1.14E-08 | 2.13E-06 | 1.450 | 2.57E-08 | 4.88E-06 |
AGT | Angiotensinogen | 1.150 | 3.09E-07 | 2.87E-05 | 1.200 | 2.05E-06 | 0.000111 |
LUM | Lumican | -0.382 | 4.81E-07 | 2.87E-05 | -0.163 | 0.00175 | 0.0121 |
TFF3 | Trefoil factor 3 | 2.590 | 8.84E-07 | 4.11E-05 | 2.160 | 2.06E-05 | 0.000522 |
OAF | Out at first protein homologue | 0.398 | 7.32E-06 | 0.000209 | 0.393 | 4.17E-05 | 0.000881 |
A1BG | α1B-Glycoprotein | 0.167 | 5.71E-05 | 0.00112 | 0.266 | 7.92E-07 | 5.02E-05 |
ABI3BP | Target of NESH-SH3 | -0.290 | 6.07E-05 | 0.00113 | -0.184 | 0.00149 | 0.0112 |
CLEC3B | Tetranectin | -0.240 | 7.65E-05 | 0.00129 | -0.158 | 0.00102 | 0.00827 |
FBN1 | Fibrillin-1 | -0.365 | 0.000114 | 0.00161 | -0.269 | 1.45E-05 | 0.000423 |
DBH | Dopamine β-hydroxylase | -0.262 | 0.000207 | 0.00242 | -0.186 | 0.00203 | 0.013 |
FGA | Fibrinogen α chain | 0.364 | 0.00076 | 0.00643 | 0.303 | 0.00741 | 0.0373 |
SPARCL1 | SPARC-like protein 1 | -0.311 | 0.0008 | 0.00661 | -0.043 | 0.508 | 0.722 |
CPN2 | Carboxypeptidase N subunit 2 | 0.161 | 0.000865 | 0.00685 | 0.190 | 0.000331 | 0.0036 |
AMBP | AMBP protein | 0.116 | 0.00283 | 0.0174 | 0.148 | 0.00061 | 0.00552 |
PEAR1 | Platelet endothelial aggregation receptor 1 | -0.650 | 0.00948 | 0.0379 | -0.722 | 0.000424 | 0.00424 |
AFM | Afamin | 0.058 | 0.119 | 0.259 | 0.177 | 0.00033 | 0.0036 |